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Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients

NCT ID: NCT00951704

Last Updated: 2018-12-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-11-30

Study Completion Date

2018-12-31

Brief Summary

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The prognosis of cardiac arrest patients is generally poor. Recent studies have showed that the high quality of CPR increases the survival after cardiac arrest. Therefore the investigators planned this prospective observational study to determine the epidemiology of sudden cardiac arrest in the prehospital setting of Tampere area, the quality of the CPR, and also the associations between depth and frequency of chest compressions and invasive arterial pressure, EtCO2,cerebral oxygenation and iatrogenic injuries associated to chest compressions 1) in patients resuscitated out of hospital by emergency medical service's (EMS's) personals and 2) in-hospital by hospital resuscitation team members. In addition, the investigators will analyze the effects of the chosen method of resuscitation on critical vital signs (Etco2 and invasive pressures): closed-chest CPR is compared to open-chest CPR, or mechanical CPR with a device (AutoPulse-CPR, Cardio Pump) compared to manual CPR guided with quality CPR device. The results will give the investigators important insights into the haemodynamics of CPR which may guide future strategies for the management of cardiac arrest. The research group is also interested in CPR related injuries and mattress effect. Quality of life after CA is evaluated among survivals and the cause of death among non-survivors.

Detailed Description

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Conditions

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Cardiac Arrest

Keywords

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CPR Tissue Perfusion invasive arterial pressure exhaled carbon dioxide Quality of life Quality of chest compressions Epidemiology of sudden cardiac arrest(OHCA)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cardiac arrest

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* cardiac arrest
* \> 18 years of age

Exclusion Criteria

* \< 18 years of age
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Turku University Hospital

OTHER_GOV

Sponsor Role collaborator

Uppsala University

OTHER

Sponsor Role collaborator

Tampere University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jyrki Tenhunen, MD, PhD

Role: STUDY_DIRECTOR

Critical Care Medicine Research Group

Sanna Hoppu, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Tampere University Hospital

Marko Sainio, MD

Role: PRINCIPAL_INVESTIGATOR

Turku University Hospital

Klaus Olkkola, MD, PhD

Role: STUDY_DIRECTOR

Department of Anesthesiology and Intensive Care, Helsinki University Hospital

Heidi Hellevuo, MD

Role: PRINCIPAL_INVESTIGATOR

Tampere University Hospital

Piritta Setälä, MD

Role: PRINCIPAL_INVESTIGATOR

Tampere University Hospital

Ilkka Virkkunen, MD, PhD

Role: STUDY_DIRECTOR

Tampere University Hospital

Heidi Kangasniemi, MD

Role: PRINCIPAL_INVESTIGATOR

Tampere University Hospital

Joonas Tamminen

Role: PRINCIPAL_INVESTIGATOR

Tampere University Hospital

Locations

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Tampere University Hospital

Tampere, Pirkanmaa, Finland

Site Status

Department of Anesthesiology and Intensive Care, Turku University Hospital

Turku, , Finland

Site Status

Countries

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Finland

References

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Kangasniemi H, Setala P, Huhtala H, Kamarainen A, Virkkunen I, Jamsen E, Yli-Hankala A, Hoppu S. Out-of-hospital cardiac arrests in nursing homes and primary care facilities in Pirkanmaa, Finland. Acta Anaesthesiol Scand. 2018 Oct;62(9):1297-1303. doi: 10.1111/aas.13152. Epub 2018 May 29.

Reference Type DERIVED
PMID: 29845604 (View on PubMed)

Setala P, Hellevuo H, Huhtala H, Kamarainen A, Tirkkonen J, Hoppu S. Risk factors for cardiopulmonary resuscitation-related injuries sustained during out-of-hospital cardiac arrests. Acta Anaesthesiol Scand. 2018 Oct;62(9):1290-1296. doi: 10.1111/aas.13155. Epub 2018 May 24.

Reference Type DERIVED
PMID: 29797706 (View on PubMed)

Setala PA, Virkkunen IT, Kamarainen AJ, Huhtala HSA, Virta JS, Yli-Hankala AM, Hoppu SE. End-tidal carbon dioxide output in manual cardiopulmonary resuscitation versus active compression-decompression device during prehospital quality controlled resuscitation: a case series study. Emerg Med J. 2018 Jul;35(7):428-432. doi: 10.1136/emermed-2017-207103. Epub 2018 May 16.

Reference Type DERIVED
PMID: 29769232 (View on PubMed)

Sainio M, Hoppu S, Huhtala H, Eilevstjonn J, Olkkola KT, Tenhunen J. Simultaneous beat-to-beat assessment of arterial blood pressure and quality of cardiopulmonary resuscitation in out-of-hospital and in-hospital settings. Resuscitation. 2015 Nov;96:163-9. doi: 10.1016/j.resuscitation.2015.08.004. Epub 2015 Aug 24.

Reference Type DERIVED
PMID: 26310837 (View on PubMed)

Sainio M, Sutton RM, Huhtala H, Eilevstjonn J, Tenhunen J, Olkkola KT, Nadkarni VM, Hoppu S. Association of arterial blood pressure and CPR quality in a child using three different compression techniques, a case report. Scand J Trauma Resusc Emerg Med. 2013 Jul 2;21:51. doi: 10.1186/1757-7241-21-51.

Reference Type DERIVED
PMID: 23819769 (View on PubMed)

Sainio M, Kamarainen A, Huhtala H, Aaltonen P, Tenhunen J, Olkkola KT, Hoppu S. Real-time audiovisual feedback system in a physician-staffed helicopter emergency medical service in Finland: the quality results and barriers to implementation. Scand J Trauma Resusc Emerg Med. 2013 Jul 1;21:50. doi: 10.1186/1757-7241-21-50.

Reference Type DERIVED
PMID: 23816325 (View on PubMed)

Hoppu S, Sainio M, Huhtala H, Eilevstjonn J, Tenhunen J, Olkkola KT. Blood pressure during resuscitation in man--the effect of pause during rhythm analysis revisited. Resuscitation. 2011 Nov;82(11):1460-3. doi: 10.1016/j.resuscitation.2011.06.005. Epub 2011 Jun 17.

Reference Type DERIVED
PMID: 21764499 (View on PubMed)

Other Identifiers

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R08116

Identifier Type: -

Identifier Source: org_study_id