CCSV

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

98 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-01

Study Completion Date

2026-09-30

Brief Summary

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The main goal of this observational study is the evaluation of Chest Compression Synchronized Ventilation (CCSV) regarding oxygenation in terms of PaO2 assessed by routine blood gas analysis, hemodynamic effects, 30-day outcome and safety in comparison to Intermittent Positive Pressure Ventilation (IPPV) as data in humans is sparse especially in direct comparison to other ventilation modes.

Cardiac arrest patients in Vienna, Austria will be preclinically randomized (IPPV and CCSV) and ventilated accordingly during CPR. Differences in oxygenation, decarboxylation, systemic perfusion and cerebral oxygenation, the patient's 30-day outcome as well as ventilator-associated adverse events (e.g., pneumothorax) will be recorded and analyzed.

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Detailed Description

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Conditions

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Cardiac Arrest

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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IPPV

Cardiac arrest patients ventilated with IPPV

No interventions assigned to this group

Cardiac arrest patients ventilated with CCSV

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* OHCA
* Correct endotracheal intubation (seen by capnography)
* The patient is being treated by the Vienna Emergency Medical Services within the scope of emergency ventilation.
* MEDUMAT Standard from Weinmann Emergency is used.
* Mechanical ventilation is performed according to the specified indications.

Exclusion Criteria

* Patients eligible for eCPR (as defined by the standard operating procedure of the Emergency Medical Service Vienna)
* Patients recovering (reaching sustained ROSC) before starting mechanical ventilation or in the first three minutes of it
* Any other mechanical ventilation during the ongoing CPR before study inclusion
* Traumatic cardiac arrest
* Suspected or known pregnancy
* Clinically suspected (tension-)pneumothorax

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No