Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2024-03-18
2024-08-21
Brief Summary
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Detailed Description
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Recently, SGAs have been adopted by emergency medical services worldwide as the primary tool for airway management during CPR. SGAs offer limited protection against aspiration compared to endotracheal intubation (ETI) and may increase the risk of aspiration. A new ventilation mode (Chest Compression Synchronized Ventilation \[CCSV\]) is now available for resuscitation with uninterrupted chest compressions.
The study investigates the influence of non-synchronized bag-device-ventilation, intermittent positive pressure ventilation (IPPV), as recommended in the current resuscitation guidelines of the ERC (Vt = 5-6 mL/kg bw, AF = 10 min-1) and CCSV (pInsp = 40 mbar; RR = chest compression rate) with regard to achieving a sufficient tidal volume and the tightness of various SGA (laryngeal mask, iGel, laryngeal tube) and endotracheal intubation.
Gender, age, height and weight are documented (external post-mortem examination). The respective body donor is randomly assigned to a group. The grouping determines the order in which the means of airway management (SGA, ETI) are used.
Initial airway management is performed with an ETI with blockage of 30 mmH2O). The body donor is then bronchoscoped. A gastric tube is placed and the pressure probe to be used is calibrated if necessary. Positive pressure ventilation (pInsp = 40 mbar, positive end-expiratory pressure (PEEP) = 12 mbar, frequency = 10 min-1) is performed for 2 minutes to recruit the lungs. Vt is documented.
Mechanical cardiopulmonary resuscitation (CPR) is then performed for minutes (4 cycles) using the mechanical chest compression device in accordance with ERC 2015. Ventilation pressure and flow curves are continuously recorded by the respirator (Medumat Standard², Weinmann GmbH). Leaks are detected via the automatically initiated ventilation curves, measured and recorded by the ventilator. Ventilation takes place for 4 minutes with bad-device-ventilation, 4 minutes in IPPV mode and 4 minutes in CCSV mode. At the end of the two cycles, the body donor is intubated with one of the remaining airway devices, and the lungs are recruited again and mechanical CPR is performed again for 12 minutes using the 3 ventilation modes.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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IPPV
Intermittend-Positive-Pressure-Ventilation
Endotracheal Intubation
Ventilation with an endotracheal tube
Laryngeal tube
Ventilation with an laryngeal tube
Laryngeal mask
Ventilation with an laryngeal mask
I-Gel-Laryngeal Mask
Ventilation with an I-Gel-laryngeal mask
CCSV
Chest Compression Synchronized Ventilation
Endotracheal Intubation
Ventilation with an endotracheal tube
Laryngeal tube
Ventilation with an laryngeal tube
Laryngeal mask
Ventilation with an laryngeal mask
I-Gel-Laryngeal Mask
Ventilation with an I-Gel-laryngeal mask
Bag-Device-Ventilation
Ventilation with a Ventilation Bag
Endotracheal Intubation
Ventilation with an endotracheal tube
Laryngeal tube
Ventilation with an laryngeal tube
Laryngeal mask
Ventilation with an laryngeal mask
I-Gel-Laryngeal Mask
Ventilation with an I-Gel-laryngeal mask
Interventions
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Endotracheal Intubation
Ventilation with an endotracheal tube
Laryngeal tube
Ventilation with an laryngeal tube
Laryngeal mask
Ventilation with an laryngeal mask
I-Gel-Laryngeal Mask
Ventilation with an I-Gel-laryngeal mask
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Severe lung or thoracic injuries
* pneumothorax
* Abnormal airways
* Tracheostoma
* severe aspirations
18 Years
100 Years
ALL
Yes
Sponsors
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Ruhr University of Bochum
OTHER
Bielefeld University
OTHER
Gerrit Jansen
OTHER
Responsible Party
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Gerrit Jansen
Principal Investigator
Locations
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JWK Minden
Minden, North Rhine-Westphalia, Germany
Countries
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References
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Gelashvili T, Brand-Saberi B, Darvishali M, Hoyer A, Kolaparambil Varghese LJ, Kuehn V, Lohmann J, Neuhaus C, Schneider C, Trenkel J, Hinkelbein J, Jansen G. Efficacy of supraglottic airway devices in chest compression synchronized ventilation during continuous resuscitation: a prospective randomized cross-over cadaver study. Resuscitation. 2025 Sep 2:110795. doi: 10.1016/j.resuscitation.2025.110795. Online ahead of print.
Other Identifiers
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IAV-2024-01
Identifier Type: -
Identifier Source: org_study_id
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