The Ventilation During In-hospital Cardiac Arrest Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

900 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-02-01

Study Completion Date

2027-01-31

Brief Summary

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The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.

The main questions it aims to answer are:

What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?

Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.

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Detailed Description

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Conditions

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Cardiac Arrest (CA) In-Hospital Cardiac Arrest Heart Arrest

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Study cohort

Adult patients (≥18 years) with in-hospital cardiac arrest receiving cardiopulmonary resuscitation.

Groups will be defined based on observed distribution of ventilation parameters (ventilation rate, tidal volume and minute ventilation).

Positive pressure ventilation during cardiopulmonary resuscitation

Intervention Type OTHER

The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation.

Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.

Interventions

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Positive pressure ventilation during cardiopulmonary resuscitation

The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation.

Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.

Intervention Type OTHER

Other Intervention Names

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manual ventilation artificial ventilation intra-arrest ventilation bag-valve-mask ventilation invasive ventilation

Eligibility Criteria

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Inclusion Criteria

1. In-hospital cardiac arrest
2. Age ≥ 18 years
3. \>1minute of recorded ventilation data

Exclusion Criteria

1. Documented do-not-attempt cardiopulmonary resuscitation order
2. Invasive mechanical circulatory support at the time of the cardiac arrest

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Johannes Wittig, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark

Kasper G Lauridsen, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark;