Application of Mechanical Cardiopulmonary Resuscitation Devices and Their Value in Out-of-hospital Cardiac Arrest: A Retrospective Analysis of the German Resuscitation Registry

NCT ID: NCT02932124

Last Updated: 2016-10-13

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 19609 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2007-01-31
• Study Completion Date: 2014-12-31

Brief Summary

The aim of this study was to analyse a large CPR database, the German Resuscitation Registry, to evaluate potential benefits of mechanical CPR devices over manual CPR in adult cardiac arrest victims. The primary endpoint considered is ROSC.

Detailed Description

In a retrospective analysis of the German Resuscitation Registry between 2007-2014, investigators examined the outcome after using mechanical CPR on return of spontaneous circulation (ROSC) in adults with out-of-hospital cardiac arrest (OHCA). Investigators compared mechanical CPR (Intervention group) to manual CPR (control group). According to preclinical risk factors, investigators calculated the predicted ROSC-after-cardiac-arrest (RACA) score for each group, and compared it to the rate of ROSC observed. Using multivariate analysis, investigators adjusted the influence of the devices' application on ROSC for epidemiological factors and therapeutic measures.

Conditions

Out-of-hospital Cardiac Arrest

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

1

manual chest compressions

No interventions assigned to this group

2

mechanical chest compression

mechanical chest compression device

Intervention Type: DEVICE

Interventions

mechanical chest compression device

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• out of hospital cardiac arrest
• during time prod from January 2007 until December 2014
• CPR attempted

Exclusion Criteria

• Investigators excluded cases in which CPR was continued for less than five minutes, or duration of CPR was missing, as the outcome in this early period is not affected by the CPR mode.
• Children aged less than 18 years and patients of unknown age were also excluded as the devices are not approved for resuscitation on children.
• An active compression-decompression (ACD) is a hand-held suction device, to compress and actively decompress the chest after each compression.
• Investigators also excluded cases where ACD CPR was used, because it constitutes a different technology.
• Cases due to trauma were excluded as application of mechanical CPR devices may be limited due in traumatic events.
• Cases where data on ROSC and/or CPR mode was missing were also excluded.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

German Resuscitation Registry

OTHER

Sponsor Role: lead

Responsible Party

Jan-Thorsten Graesner, MD

PD Dr.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jan Wnent, MD

Role: PRINCIPAL_INVESTIGATOR

German Resuscitation Registry

Other Identifiers

GRR-CC07-14

Identifier Type: -

Identifier Source: org_study_id