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Brachial Artery Peak Velocity Variation to Predict Fluid Responsiveness

NCT ID: NCT00890071

Last Updated: 2009-04-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

38 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-12-31

Study Completion Date

2009-04-30

Brief Summary

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The investigators designed this study to determine the predictive value for predicting fluid responsiveness of noninvasive evaluation of respiratory variation of peak velocity in brachial artery, in mechanically ventilated patients with acute circulatory failure.

Detailed Description

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Predicting the hemodynamic response to fluid administration (or fluid responsiveness) in critical ill patients is still a matter of concern, since fluid overload could worse the clinical situation of these patients. Parameters of fluid responsiveness usually require an invasive monitoring (like arterial pulse pressure variation).

We hypothesize that noninvasive evaluation of respiratory variation of peak velocity in brachial artery using Doppler ultrasound could provide a feasible estimation on fluid responsiveness in mechanically ventilated patients with acute circulatory failure.

Conditions

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Hypotension Shock

Keywords

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Fluid responsiveness Ultrasound Cardiac output

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Acute circulatory failure

Patients for whom the decision to give fluids was taken because the presence of one or more clinical signs of acute circulatory failure.

Fluid administration

Intervention Type OTHER

500 ml of synthetic colloid (Voluven®, hydroxyethylstarch 6%; Fresenius, Bad Homburg, Germany) infused over 30 minutes

Interventions

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Fluid administration

500 ml of synthetic colloid (Voluven®, hydroxyethylstarch 6%; Fresenius, Bad Homburg, Germany) infused over 30 minutes

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with controlled mechanical ventilation, equipped with an indwelling radial artery catheter and for whom the decision to give fluids will be taken because the presence of one or more clinical signs of acute circulatory failure:

* systolic blood pressure \<90 mmHg (or a decrease \>50 mmHg in previously hypertensive patients)
* the need of vasopressor drugs
* oliguria (urine output \<0.5 ml/kg/min for at least 2 h)
* tachycardia
* delayed capillary refilling
* the presence of skin mottling

Exclusion Criteria

* Contraindication for the volume administration: evidence of fluid overload and/or of hydrostatic pulmonary edema
* Patients with instable cardiac rhythm
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital del SAS de Jerez

OTHER

Sponsor Role lead

Responsible Party

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Hospital del SAS de Jerez

Principal Investigators

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M. Ignacio Monge García

Role: PRINCIPAL_INVESTIGATOR

Hospital del SAS de Jerez

Locations

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Hospital del SAS de Jerez

Jerez de la Frontera, Cádiz, Spain

Site Status

Countries

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Spain

References

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Monge Garcia MI, Gil Cano A, Diaz Monrove JC. Brachial artery peak velocity variation to predict fluid responsiveness in mechanically ventilated patients. Crit Care. 2009;13(5):R142. doi: 10.1186/cc8027. Epub 2009 Sep 3.

Reference Type DERIVED
PMID: 19728876 (View on PubMed)

Other Identifiers

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UIE-SCCU-200902

Identifier Type: -

Identifier Source: org_study_id