Acute High Fat Bulletproof Coffee vs Black Coffee on Metabolism, Inflammation and Cognitive Function in Healthy Adults

NCT ID: NCT04307979

Last Updated: 2020-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-01

Study Completion Date

2020-12-31

Brief Summary

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This study will determine whether acute ingestion of a high fat "Bulletproof Coffee" will lead to changes in plasma triglycerides, immune cell function, as well as cognitive function when compared to a black coffee.

Detailed Description

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In a randomized crossover design, participants will consume a single bulletproof coffee or a single black coffee separated by \~7 days. Each visit commences in the morning after an overnight fast of 10-12 hours, with no exercise the day prior, no coffee consumption the morning of testing, and completion of a food log for dietary duplication prior to visit 2. A fasting blood draw is obtained and cognitive function tests administered, along with questionnaires to assess gastrointestinal distress, arousal, and hunger/fullness before coffee consumption. Following this, one of the coffee beverages is consumed (randomized to each visit). Cognitive testing and questionnaires are completed at 60 minutes after finishing the coffee, another blood draw at 90 minutes, and then cognitive testing, questionnaires and a final blood draw 180 minutes after consuming the coffee. This procedure is repeated during their second experimental visit, in which they consume the remaining coffee based on their randomization.

Conditions

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Leukocytosis Triglycerides Cognitive Function Inflammatory Response

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Randomized double-blind crossover design.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Bulletproof Coffee

A black coffee (bullet proof coffee keurig pod) with 29 grams of added fat (1 tablespoon bullet proof brain octane medium chain triglyceride oil, and 1 tablespoon bullet proof grass fed ghee) blended for 20 seconds with butter scent that is added to the lid.

Group Type EXPERIMENTAL

High-fat coffee

Intervention Type DIETARY_SUPPLEMENT

A high fat coffee that consists of 29 grams of added fat from grass fed ghee, and MCT oil.

Black coffee

Intervention Type DIETARY_SUPPLEMENT

A regular black coffee with no added caloric content.

Black Coffee

Black coffee that is blended for 20 seconds with butter scent added to the top of the lid.

Group Type PLACEBO_COMPARATOR

High-fat coffee

Intervention Type DIETARY_SUPPLEMENT

A high fat coffee that consists of 29 grams of added fat from grass fed ghee, and MCT oil.

Black coffee

Intervention Type DIETARY_SUPPLEMENT

A regular black coffee with no added caloric content.

Interventions

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High-fat coffee

A high fat coffee that consists of 29 grams of added fat from grass fed ghee, and MCT oil.

Intervention Type DIETARY_SUPPLEMENT

Black coffee

A regular black coffee with no added caloric content.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Must be over the age of 18
* Must drink between 1-4 cups of coffee per day (on average)
* Must be able to tolerate lactose and dairy products
* Have not been sick for the past 3 weeks (immune function)
* Non smoker
* Must be able to fast for 10-12 hours

Exclusion Criteria

* If you are required to take corticosteroids (immune function)
* Cannot understand or speak English
* Individual has an auto-immune disease and requires medication
* Individual is following a ketogenic diet
* Individual has allergy or sensitivity to dairy, coffee or caffeine or coconut oil
* Individual has hypertension
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of British Columbia

OTHER

Sponsor Role lead

Responsible Party

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Jonathan Little

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jonathan P Little, PhD

Role: PRINCIPAL_INVESTIGATOR

University of British Columbia- Okanagan

Locations

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University of British Columbia, Okanagan.

Kelowna, British Columbia, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Garett S Jackson, B.H.K

Role: CONTACT

1-250-807-9122

Jonathan P Little, PhD

Role: CONTACT

1-250-878-6893

Facility Contacts

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Jonathan P Little, PHD

Role: primary

1-250-878-6893

Garett S Jackson, B.H.K

Role: backup

1-250 807 9122

Other Identifiers

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H19-02684

Identifier Type: OTHER

Identifier Source: secondary_id

Bulletproof Coffee

Identifier Type: -

Identifier Source: org_study_id

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