The Role of Dietary Fat on Postprandial Endotoxemia in Healthy Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-04-30

Study Completion Date

2015-04-30

Brief Summary

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The purpose of this study was to determine the effect of different dietary fats (saturated or unsaturated) on postprandial endotoxemia and systemic low grade acute inflammation. The investigators hypothesized that meals rich in saturated or n-6 fatty acids would increase postprandial endotoxemia but meals high in n-3 fatty acids would decrease postprandial endotoxemia.Participants were recruited via email and randomized to treatment meal in this single-blind, cross-over study. Each test session participants reported to the laboratory right away in the morning. An indwelling catheter was inserted into the participant non-dominant arm by a qualified nurse and a baseline blood draw was taken. The participant was then provided with one of four test meals (a porridge-type meal containing a different dietary fat), which they ate in entirety within 15 minutes. The participants remained in the laboratory for the next five and a half hours and were not allowed to consume any food or drink except water. During this time, further blood draws were taken at intervals of one hour for a total of five hours after the consumption of the test meal. Collected blood was processed on-site and the serum fraction collected and tested for endotoxin, inflammatory biomarkers, and metabolites.

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Detailed Description

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Conditions

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Endotoxemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Test Meal Saturated Fat

Saturated-fat Treatment Meal

Group Type EXPERIMENTAL

Saturated-fat Treatment Meal

Intervention Type OTHER

Isocaloric test meal that provided 35% fat with saturated fat (16 g).

Test Meal N-6 Fat

N-6 fat Treatment Meal.

Group Type EXPERIMENTAL

N-6 fat Treatment Meal

Intervention Type OTHER

Isocaloric test meal that provided 35% fat with n-6 (7.4 g).

Test Meal N-3 Fat

N-3 fat Treatment Meal.

Group Type EXPERIMENTAL

N-3 fat Treatment Meal

Intervention Type OTHER

Isocaloric test meal that provided 35% fat with n-3 (DHA = 500mg)

Test Meal Low-fat

Low-fat Treatment Meal.

Group Type EXPERIMENTAL

Low-fat Treatment Meal

Intervention Type OTHER

Isocaloric test meal that provided 20% fat.

Interventions

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Low-fat Treatment Meal

Isocaloric test meal that provided 20% fat.

Intervention Type OTHER

Saturated-fat Treatment Meal

Isocaloric test meal that provided 35% fat with saturated fat (16 g).

Intervention Type OTHER

N-3 fat Treatment Meal

Isocaloric test meal that provided 35% fat with n-3 (DHA = 500mg)

Intervention Type OTHER

N-6 fat Treatment Meal

Isocaloric test meal that provided 35% fat with n-6 (7.4 g).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged between 18 and 40 years old;
* Willingness to eat test meals;
* Body mass index ≥ 19.9 ±0.8 and ≤ 24.9 ±0.8;
* Weight stable (\< 2 kilogram weight change in the previous 3 months)

Exclusion Criteria

* Presence of acute or chronic disease;
* Use of tobacco products;
* Consumes more than 21 units of alcohol per week;
* Use of anti-inflammatory medication;
* History suggestive of macronutrient malabsorption

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes