Effect of High-carbohydrate or High-monounsaturated Fat on Blood Pressure: Meta-analysis of Randomized Clinical Trials

NCT ID: NCT02626325

Last Updated: 2016-07-06

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 1000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-11-30
• Study Completion Date: 2016-07-31

Brief Summary

High saturated fat acids diets are associated with elevated blood pressure which is associated with cardiovascular morbidity and mortality. For this reason, a change of diet is recommended to manage blood pressure and prevent cardiovascular complications. To achieve this nutritional goal, a high-carbohydrate diet or high-monounsaturated fat diet can be advised in the replacement of a saturated fat diet.

Previous meta-analysis of Garg (1998) cited randomized articles with inconsistent blood pressure lowering after consumption of a high-monounsaturated-fat diet compared with a high-carbohydrate diet only in type 2 diabetes patients. Moreover, another meta-analysis of Shah et al. (2007) showed slightly high blood pressure on diets rich in carbohydrates than diets rich in cis-monounsaturated fat after randomized and nonrandomized articles.

For this reason, a new meta-analysis of a randomized clinical trial will be performed to clarify the effects of high-carbohydrate or high-monounsaturated fat diets on blood pressure. Results from this meta-analysis will help health professionals take important decisions on patient diet and minimize cardiovascular morbidity and mortality.

Conditions

Blood Pressure

Study Design

• Study Time Perspective: RETROSPECTIVE

Interventions

High-carbohydrate or High-monounsaturated fat diets

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Randomized controlled trials
• Parallel or Crossover Design
• Duration: at least 3 weeks
• Isocaloric diet

• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Unity Health Toronto

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Vladimir Vuksan, PhD

Role: PRINCIPAL_INVESTIGATOR

Unity Health Toronto

Elena Jovanovskie, MSc

Role: PRINCIPAL_INVESTIGATOR

Unity Health Toronto

Any de Castro Ruiz Marques, MSc

Role: STUDY_DIRECTOR

Unity Health Toronto

Locations

Vladimir Vuksan

Toronto, Ontario, Canada

Countries

Canada

References

Jovanovski E, de Castro Ruiz Marques A, Li D, Ho HVT, Blanco Mejia S, Sievenpiper JL, Zurbau A, Komishon A, Duvnjak L, Bazotte RB, Vuksan V. Effect of high-carbohydrate or high-monounsaturated fatty acid diets on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2019 Jan 1;77(1):19-31. doi: 10.1093/nutrit/nuy040.

Reference Type: DERIVED

PMID: 30165599 (View on PubMed)

Other Identifiers

CHO-MUFA Meta

Identifier Type: -

Identifier Source: org_study_id