Comparison of Dietary Fats on Vascular Parameters

NCT ID: NCT01876394

Last Updated: 2016-03-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Study Completion Date

2016-06-30

Brief Summary

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The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Coconut oil

Group Type EXPERIMENTAL

Coconut Oil

Intervention Type OTHER

Shake with 50 g Coconut oil

Canola Oil

Intervention Type OTHER

Shake with 50 g Canola oil

Grapeseed Oil

Intervention Type OTHER

Shake with 50 g Grapeseed oil

Chia Oil

Intervention Type OTHER

Shake with 50 g Chia oil

Butter

Intervention Type OTHER

Shake with 50 g Butter

Canola oil

Group Type EXPERIMENTAL

Coconut Oil

Intervention Type OTHER

Shake with 50 g Coconut oil

Canola Oil

Intervention Type OTHER

Shake with 50 g Canola oil

Grapeseed Oil

Intervention Type OTHER

Shake with 50 g Grapeseed oil

Chia Oil

Intervention Type OTHER

Shake with 50 g Chia oil

Butter

Intervention Type OTHER

Shake with 50 g Butter

Grapeseed oil

Group Type EXPERIMENTAL

Coconut Oil

Intervention Type OTHER

Shake with 50 g Coconut oil

Canola Oil

Intervention Type OTHER

Shake with 50 g Canola oil

Grapeseed Oil

Intervention Type OTHER

Shake with 50 g Grapeseed oil

Chia Oil

Intervention Type OTHER

Shake with 50 g Chia oil

Butter

Intervention Type OTHER

Shake with 50 g Butter

Chia oil

Group Type EXPERIMENTAL

Coconut Oil

Intervention Type OTHER

Shake with 50 g Coconut oil

Canola Oil

Intervention Type OTHER

Shake with 50 g Canola oil

Grapeseed Oil

Intervention Type OTHER

Shake with 50 g Grapeseed oil

Chia Oil

Intervention Type OTHER

Shake with 50 g Chia oil

Butter

Intervention Type OTHER

Shake with 50 g Butter

Butter

Group Type PLACEBO_COMPARATOR

Coconut Oil

Intervention Type OTHER

Shake with 50 g Coconut oil

Canola Oil

Intervention Type OTHER

Shake with 50 g Canola oil

Grapeseed Oil

Intervention Type OTHER

Shake with 50 g Grapeseed oil

Chia Oil

Intervention Type OTHER

Shake with 50 g Chia oil

Butter

Intervention Type OTHER

Shake with 50 g Butter

Interventions

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Coconut Oil

Shake with 50 g Coconut oil

Intervention Type OTHER

Canola Oil

Shake with 50 g Canola oil

Intervention Type OTHER

Grapeseed Oil

Shake with 50 g Grapeseed oil

Intervention Type OTHER

Chia Oil

Shake with 50 g Chia oil

Intervention Type OTHER

Butter

Shake with 50 g Butter

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy
* Age 18-65 years
* BMI \< 30 kg/m2
* Brachial systolic blood pressure ≤ 140 mmHg
* Brachial diastolic blood pressure ≤ 90 mmHg

Exclusion Criteria

* Women of childbearing age must not be pregnant or breastfeeding at the time of the study
* BMI \>35kg/m2
* Hypertensive as defined by brachial SBP \>140mmHg and/or DBP \>90mmHg
* Sensitivity to the study product or its sources
* Presence of chronic conditions or illnesses
* Having any gastrointestinal complication or condition
* Chronic use of dietary supplements that alter fat absorption
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Unity Health Toronto

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vuksan Vladimir, PhD

Role: PRINCIPAL_INVESTIGATOR

Risk Factor Modification Centre - St. Michael's Hospital

Alexandra Jenkins (Co-investigator), PhD, RD

Role: PRINCIPAL_INVESTIGATOR

Unity Health Toronto

William Watson (Qualified investigator), MD

Role: PRINCIPAL_INVESTIGATOR

Unity Health Toronto

Elena Jovanovski (Co-investigator), MSc

Role: PRINCIPAL_INVESTIGATOR

Unity Health Toronto

Locations

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Risk Factor Modification Centre, St. Michael's Hospital

Toronto, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Thanh Ho, BSc

Role: CONTACT

416-864-6060 ext. 2087

Other Identifiers

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COIL

Identifier Type: -

Identifier Source: org_study_id

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