Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals
NCT ID: NCT07183488
Last Updated: 2025-11-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
10 participants
INTERVENTIONAL
2025-09-10
2030-09-01
Brief Summary
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The hypothesis is that plasma ketone body levels will increase during the first three hours after intake of butyrate, but not propionate, in healthy individuals in the overnight fasted state.
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Detailed Description
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The day prior to the experimental days, participants will consume a standardized control dinner and evening snack and abstain from alcohol and vigorous physical activity to ensure similar conditions on the experimental days. The standardized meal will be provided to the participants. On the test days, participants will be instructed to arrive by passive transport in an overnight fasted state (10 hours). Upon arrival, a DXA scan will be performed, after which a catheter will be inserted into an antecubital vein. Following 30 minutes of supine rest, baseline measurements will be performed, including indirect calorimetry, blood pressure measurement, flow-mediated vasodilation (FMD), and a fasting venous blood sample. Participants will then ingest 3 grams of propionate or butyrate within 5 minutes, together with 250 ml of water. After ingestion, participants will remain resting in bed for 3 hours, during which blood samples (15 ml each) will be collected continuously throughout the test day. Indirect calorimetry, blood pressure measurements, and FMD will be repeated at various time points post-ingestion. The test day will end with an ad libitum meal. The entire procedure will be repeated on the second test day.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Female
Propionate followed by Butyrate
• The participants will consume Short-Chain Fatty Acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
Butyrate followed by Propionate
The participants will consume Short-Chain Fatty Acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
Male
Propionate followed by Butyrate
The participants will consume Short-chain fatty acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
Butyrate followed by Propionate
• The participants will consume Short-chain fatty acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
Interventions
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Propionate followed by Butyrate
The participants will consume Short-chain fatty acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
Butyrate followed by Propionate
• The participants will consume Short-chain fatty acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
Propionate followed by Butyrate
• The participants will consume Short-Chain Fatty Acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
Butyrate followed by Propionate
The participants will consume Short-Chain Fatty Acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
Eligibility Criteria
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Inclusion Criteria
* Age between 18-40 years old
* BMI between 18.5-29
Exclusion Criteria
* Kidney- or liver disease
* Pregnant, lactating or planning to become pregnant within the study period
* Supplementation with SCFAs
* Supplementation with B12 vitamin
* Special dietary habits (e.g. vegan/ketogenic diet)
* Ongoing cancer treatment
* Metabolic or absorptive disorders, gastric bypass operation, or use of medication affecting metabolism or food absorption
* Crohn's disease, ulcerative colitis or short bowel syndrome
* Inability, physically or mentally, to comply with the procedure required by the study protocol as evaluated by the primary investigator, study manager or clinical responsible
18 Years
40 Years
ALL
Yes
Sponsors
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University of Copenhagen
OTHER
Responsible Party
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Locations
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University of Copenhagen
Copenhagen, Copenhagen N, Denmark
Countries
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Central Contacts
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Facility Contacts
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Andreas M Fritzen, Associate Professor
Role: backup
Other Identifiers
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H-25038908
Identifier Type: -
Identifier Source: org_study_id
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