Effects of Canola Oil and Coconut Oil on Postprandial Metabolism in Older Adults With Increased Cardiometabolic Risk

NCT ID: NCT05208346

Last Updated: 2025-04-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-03-09
• Study Completion Date: 2022-10-18

Brief Summary

The aim of this study is to investigate the postprandial effects of fat content and fatty acid composition of mixed meals on parameters associated with cardiometabolic diseases. Therefore, older subjects with increased risk of cardiometabolic diseases consume 4 mixed meals with 25 or 50 g of either canola or coconut oil. In a postprandial period of 6 hours, outcomes associated with cardiometabolic risk (e.g., triglycerides) are analyzed.

Detailed Description

In a crossover design, 30 older men and women with increased risk of cardiometabolic diseases consume 4 mixed meals, enriched with either 25 or 50 g canola or coconut oil. During a postprandial period of 6 hours, parameters of lipid metabolism (e.g., plasma triglycerides), glucose metabolism (e.g., plasma glucose, serum insulin), as well as markers of inflammation (e.g., IL-6), vascular system (e.g., pulse wave velocity) and antioxidant system (e.g., trolox equivalent antioxidative capacity) are analyzed. Furthermore, fatty acid profile, neuropsychologic parameters (e.g., attention), subjective feeling of hunger and satiety, and satiety-associated hormones (e.g., ghrelin) are assessed. Each intervention arm will be separated by a washout period of about 14 days.

Conditions

Cardiovascular Diseases; Metabolic Syndrome

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

Canola oil high-fat

Participants randomized to receive a mixed meal with 50 g canola oil

Group Type: EXPERIMENTAL

Mixed meals

Intervention Type: DIETARY_SUPPLEMENT

Mixed meals enriched with either 25 or 50 g of canola or coconut oil

Coconut oil high-fat

Participants randomized to receive a mixed meal with 50 g coconut oil

Group Type: EXPERIMENTAL

Mixed meals

Intervention Type: DIETARY_SUPPLEMENT

Mixed meals enriched with either 25 or 50 g of canola or coconut oil

Canola oil low-fat

Participants randomized to receive a mixed meal with 25 g canola oil

Group Type: EXPERIMENTAL

Mixed meals

Intervention Type: DIETARY_SUPPLEMENT

Mixed meals enriched with either 25 or 50 g of canola or coconut oil

Coconut oil low-fat

Participants randomized to receive a mixed meal with 25 g coconut oil

Group Type: EXPERIMENTAL

Mixed meals

Intervention Type: DIETARY_SUPPLEMENT

Mixed meals enriched with either 25 or 50 g of canola or coconut oil

Interventions

Mixed meals

Mixed meals enriched with either 25 or 50 g of canola or coconut oil

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• BMI: 27 - 34,9 kg/m2
• Waist circumference: women ≥ 80 cm, men ≥ 94 cm
• At least two of the following criteria of metabolic syndrome:

Fasting triglycerides in serum: ≥ 150 mg/dl Fasting HDL-Cholesterol in serum: women < 50 mg/dl, men < 40 mg/dl Systolic blood pressure: ≥ 130 mmHg, diastolic blood pressure: ≥ 85 mmHg Fasting glucose in plasma: ≥ 100 mg/dL

Exclusion Criteria

• Smoking
• Diseases that may impact outcome measures (e.g., thyroid diseases, insulin-dependent diabetes mellitus, impaired renal function, tumors, anemia)
• Intake of immunosuppressives or supplements (e.g., fish oil)
• Participation in another study

• Minimum Eligible Age: 60 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Union for the Promotion of Oil and Protein Plants (UFOP, Germany)

UNKNOWN

Sponsor Role: collaborator

University of Bonn

OTHER

Sponsor Role: lead

Responsible Party

Prof. Dr. Sarah Egert

Prof. Dr. Sarah Egert

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Sarah Egert, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

University of Bonn

Locations

University of Bonn

Bonn, , Germany

Countries

Germany

Other Identifiers

528/191

Identifier Type: -

Identifier Source: org_study_id