The Impact of Short-Chain Fatty Acids on Gut Hormone Release After Delivery in the Small and Large Intestine of Healthy Volunteers
NCT ID: NCT06686888
Last Updated: 2024-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
27 participants
INTERVENTIONAL
2024-09-25
2025-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Small intestinal delivery capsules
SCFA
SCFA
On test days participants will ingest the capsules during a standard no fiber breakfast. Blood samples will be collected at regular time points for 8 hours. A visual analogue scale that questions hunger and satiety will be completed at regular time points.
Colon-delivery capsules
SCFA
SCFA
On test days participants will ingest the capsules during a standard no fiber breakfast. Blood samples will be collected at regular time points for 8 hours. A visual analogue scale that questions hunger and satiety will be completed at regular time points.
placebo capsules
Microcristalline cellulose
microcristalline cellulose
On test days participants will ingest the capsules during a standard no fiber breakfast. Blood samples will be collected at regular time points for 8 hours. A visual analogue scale that questions hunger and satiety will be completed at regular time points.
Interventions
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SCFA
On test days participants will ingest the capsules during a standard no fiber breakfast. Blood samples will be collected at regular time points for 8 hours. A visual analogue scale that questions hunger and satiety will be completed at regular time points.
microcristalline cellulose
On test days participants will ingest the capsules during a standard no fiber breakfast. Blood samples will be collected at regular time points for 8 hours. A visual analogue scale that questions hunger and satiety will be completed at regular time points.
Eligibility Criteria
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Inclusion Criteria
* healthy
* normal BMI (18.5-25 kg/m\^2)
* age within 18-50 years
Exclusion Criteria
* Previous abdominal surgery, except from appendectomy
* Being on a weight loss, gluten-free, lactose-free, or vegan diet
* The donation of blood during the last 3 months or suffering from low blood haemoglobin levels
* The use of antibiotics or other medication that affects the gastrointestinal tract 3 months preceding the study and/or during the study
* The use of prebiotics or probiotics 2 weeks preceding the study and/or during the study
* Pregnancy, lactation or wish to become pregnant during the study period
* Previous or current substance/alcohol dependence or abuse (\> 2 units per day/14 units per week)
18 Years
50 Years
ALL
Yes
Sponsors
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KU Leuven
OTHER
Responsible Party
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Kristin Verbeke
Prof.
Locations
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KU Leuven
Leuven, , Belgium
Countries
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Central Contacts
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Facility Contacts
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Riet Rosseel, Msc
Role: primary
Kristin Verbeke, Prof
Role: backup
Other Identifiers
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S67256- study 2
Identifier Type: -
Identifier Source: org_study_id