Fatty Acid Biomarkers of Carbohydrate Intake

NCT ID: NCT03295448

Last Updated: 2018-11-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

19 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-25

Study Completion Date

2018-06-01

Brief Summary

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The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.

Detailed Description

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In this isocaloric clinical cross-over trial, the investigators aim to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality. The investigators intend to evaluate if changes in carbohydrate quantity and quality (including sugar) influence circulating even-chain saturated fatty acids or if fatty acid-derived indices of desaturation and de novo lipogenesis are more sensitive biomarkers of carbohydrate intake. By performing untargeted lipidomic analyses, the investigators aim to search for novel lipid biomarkers of carbohydrate quantity and quality. The investigators also want to evaluate the influence of moderate alterations of carbohydrate and sugar intake on lipoproteins, insulin sensitivity, inflammatory proteins.

Conditions

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Dyslipidemias

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Fat - Sugar - Fiber

Intervention: consuming diets rich in fat, rich in sugar, and rich in fibers during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Group Type ACTIVE_COMPARATOR

Low carbohydrate diet

Intervention Type OTHER

Diet low in carbohydrates (38%E), but higher in total and saturated fat.

High carbohydrate, high sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.

High carbohydrate, low sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.

Fat - Fiber - Sugar

Intervention: consuming diets rich in fat, rich in fiber, and rich sugar during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Group Type ACTIVE_COMPARATOR

Low carbohydrate diet

Intervention Type OTHER

Diet low in carbohydrates (38%E), but higher in total and saturated fat.

High carbohydrate, high sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.

High carbohydrate, low sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.

Sugar - Fiber - Fat

Intervention: Consuming diets rich in sugar, rich in fiber, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Group Type ACTIVE_COMPARATOR

Low carbohydrate diet

Intervention Type OTHER

Diet low in carbohydrates (38%E), but higher in total and saturated fat.

High carbohydrate, high sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.

High carbohydrate, low sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.

Sugar - Fat - Fiber

Intervention: Consuming diets rich in sugar, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Group Type ACTIVE_COMPARATOR

Low carbohydrate diet

Intervention Type OTHER

Diet low in carbohydrates (38%E), but higher in total and saturated fat.

High carbohydrate, high sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.

High carbohydrate, low sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.

Fiber - Sugar - Fat

Intervention: Consuming diets rich in fiber, rich in sugar, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Group Type ACTIVE_COMPARATOR

Low carbohydrate diet

Intervention Type OTHER

Diet low in carbohydrates (38%E), but higher in total and saturated fat.

High carbohydrate, high sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.

High carbohydrate, low sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.

Fiber - Fat - Sugar

Intervention: consuming diets rich in fiber, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Group Type ACTIVE_COMPARATOR

Low carbohydrate diet

Intervention Type OTHER

Diet low in carbohydrates (38%E), but higher in total and saturated fat.

High carbohydrate, high sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.

High carbohydrate, low sugar diet

Intervention Type OTHER

Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.

Interventions

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Low carbohydrate diet

Diet low in carbohydrates (38%E), but higher in total and saturated fat.

Intervention Type OTHER

High carbohydrate, high sugar diet

Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.

Intervention Type OTHER

High carbohydrate, low sugar diet

Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI 20-38

Exclusion Criteria

* abnormal lab tests (assessed by screening and judged by a physician), diabetes, cardiovascular, kidney, liver or malignant disease, and weight-loss (±3kg) the preceding 3 months of screening. Extreme diets, i.e. very-low carbohydrate diets, intermittent fasting, vegan diets or allergic to gluten
Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Uppsala University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ulf Riserus, PhD

Role: PRINCIPAL_INVESTIGATOR

Uppsala University

Locations

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Uppsala univeristy hospital

Uppsala, , Sweden

Site Status

Countries

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Sweden

References

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Bajahzer MF, Rosqvist F, Friden M, Iggman D, Pingel R, Marklund M, Riserus U. Contrasting Carbohydrate Quantity and Quality and the Effects on Plasma Saturated and Monounsaturated Fatty Acids in Healthy Adults: A Randomized Controlled Trial. J Nutr. 2023 Mar;153(3):683-690. doi: 10.1016/j.tjnut.2023.01.005. Epub 2023 Jan 13.

Reference Type DERIVED
PMID: 36797136 (View on PubMed)

Other Identifiers

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CARBIO

Identifier Type: -

Identifier Source: org_study_id

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