Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2015-03-31
2015-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
TRIPLE
Study Groups
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Soybean oil
Soybean oil
Participants will be fed soybean oil as part of a controlled (typical American) diet.
High-oleic soybean oil
High-oleic soybean oil
Participants will be fed high-oleic soybean oil as part of a controlled (typical American) diet.
High-oleic soybean oil + fully hydrogenated soybean oil
High-oleic soybean oil + fully hydrogenated soybean oil
Participants will be fed a blend of high-oleic soybean oil and fully hydrogenated soybean oil as part of a controlled (typical American) diet.
Palm olein + palm stearin
Palm olein + palm stearin
Participants will be fed a blend of palm olein + palm stearin as part of a controlled (typical American) diet.
Interventions
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Soybean oil
Participants will be fed soybean oil as part of a controlled (typical American) diet.
High-oleic soybean oil
Participants will be fed high-oleic soybean oil as part of a controlled (typical American) diet.
High-oleic soybean oil + fully hydrogenated soybean oil
Participants will be fed a blend of high-oleic soybean oil and fully hydrogenated soybean oil as part of a controlled (typical American) diet.
Palm olein + palm stearin
Participants will be fed a blend of palm olein + palm stearin as part of a controlled (typical American) diet.
Eligibility Criteria
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Inclusion Criteria
* LDL-cholesterol between 120 and 160 mg/dl
* Less than 2+ risk factors for coronary heart disease (risk factors include: blood pressure \> 140/90 mm Hg or on blood pressure medication; HDL-cholesterol \< 40 mg/dl; age greater than 45 yrs for males \& greater than 55 yrs for females; family history of premature coronary heart disease (CHD in male first degree relative \<55 years; CHD in female first degree relative \<65 years)
Exclusion Criteria
* Use of prescription or over-the-counter medications or supplements that alter lipid metabolism.
* Women who have given birth during the previous 12 months
* Pregnant women or women who plan to become pregnant or become pregnant during the study
* Lactating women
* Type 2 diabetes requiring the use of oral antidiabetic agents or insulin
* History of bariatric or certain other surgeries related to weight control
* Use of prescription or over-the-counter antiobesity medications or supplements (e.g., phenylpropanolamine, ephedrine, caffeine) during and for at least 6 months prior to the start of the study or a history of a surgical intervention for obesity
* Unwillingness to abstain from herbal supplements for two weeks prior to the study and during the study
* Smokers or other tobacco users (during 6 months prior to the start of the study)
* History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets)
* Known (self-reported) allergy or adverse reaction to study foods
* Active cardiovascular disease (such as a heart attack or procedure within the past three months or participation in a cardiac rehabilitation program within the last three months, stroke, or history/treatment for transient ischemic attacks in the past three months, or documented history of pulmonary embolus in the past six months)
* Unable or unwilling to give informed consent or communicate with study staff
* Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)
* Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol
30 Years
70 Years
ALL
Yes
Sponsors
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USDA Beltsville Human Nutrition Research Center
FED
Responsible Party
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David Baer
Research Physiologist
Locations
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USDA-ARS, Beltsville Human Nutrition Research Center
Beltsville, Maryland, United States
Countries
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Other Identifiers
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HS50
Identifier Type: -
Identifier Source: org_study_id
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