Metabolic Consequences of Moderate Weight Gain - Role of Dietary Fat Composition (LIPOGAIN)
NCT ID: NCT01427140
Last Updated: 2011-12-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
41 participants
INTERVENTIONAL
2011-09-30
2011-12-31
Brief Summary
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Detailed Description
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* Investigate if dietary fat composition influences liver fat accumulation and metabolic risk factors in response to moderate weight gain
* Investigate if polyunsaturated fat (PUFA) in the diet could counteract any unfavorable metabolic changes that are expected to accompany moderate weight gain
* Investigate effects of weight gain and dietary fat composition on markers of vascular health
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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Saturated fatty acid group
Addition of saturated fatty acids to the diet inte the form of pastries
Saturated fatty acid group
Addition of saturated fatty acids to the diet in the form of pastries
Polyunsaturated fatty acid group
Addition of polyunsaturated fatty acids to the diet in the form of pastries
Polyunsaturated fatty acid group
Addition of polyunsaturated fatty acids to the diet in the form of pastries
Interventions
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Polyunsaturated fatty acid group
Addition of polyunsaturated fatty acids to the diet in the form of pastries
Saturated fatty acid group
Addition of saturated fatty acids to the diet in the form of pastries
Eligibility Criteria
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Inclusion Criteria
* Body Mass Index 18-27
Exclusion Criteria
* Coronary heart disease,
* Diabetes mellitus,
* Malignant diseases,
* Alcohol or drug abuse,
* Magnetic Resonance-incompatibility,
* Abnormal clinical chemistry,
* Use of drugs that significantly effects energy metabolism,
* Heavy exercise,
* Pregnancy or lactation,
* Allergy of gluten, egg or milk protein
20 Years
38 Years
ALL
Yes
Sponsors
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Uppsala University
OTHER
Responsible Party
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Principal Investigators
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Ulf Risérus, Ass. professor
Role: PRINCIPAL_INVESTIGATOR
Clinical Nutrition and Metabolism, Dept. of Public Health and Caring Sciences, Uppsala University
Locations
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Uppsala University Hospital, Uppsala Science Park
Uppsala, , Sweden
Countries
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References
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Rosqvist F, Orho-Melander M, Kullberg J, Iggman D, Johansson HE, Cedernaes J, Ahlstrom H, Riserus U. Abdominal Fat and Metabolic Health Markers but Not PNPLA3 Genotype Predicts Liver Fat Accumulation in Response to Excess Intake of Energy and Saturated Fat in Healthy Individuals. Front Nutr. 2020 Dec 3;7:606004. doi: 10.3389/fnut.2020.606004. eCollection 2020.
Perfilyev A, Dahlman I, Gillberg L, Rosqvist F, Iggman D, Volkov P, Nilsson E, Riserus U, Ling C. Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial. Am J Clin Nutr. 2017 Apr;105(4):991-1000. doi: 10.3945/ajcn.116.143164. Epub 2017 Mar 8.
Iggman D, Rosqvist F, Larsson A, Arnlov J, Beckman L, Rudling M, Riserus U. Role of dietary fats in modulating cardiometabolic risk during moderate weight gain: a randomized double-blind overfeeding trial (LIPOGAIN study). J Am Heart Assoc. 2014 Oct 15;3(5):e001095. doi: 10.1161/JAHA.114.001095.
Other Identifiers
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SLS-2011-LPG
Identifier Type: -
Identifier Source: org_study_id