Macronutrient Relations and Weight Loss in Obese Subjects

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-11-30

Study Completion Date

2007-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The burden of overweight and obesity has dramatically increased during the last decades. High carbohydrate intake, particularly refined carbohydrates, probably increase the risk of obesity, type 2 diabetes, and metabolic syndrome. There is evidence that energy-restricted low-carbohydrate diets show greater weight loss and better improvement of cardiovascular risk markers compared to energy-restricted low-fat diets. Beside macronutrient relations, efficacy of weight loss programs depends on care and control. The investigators aim to investigate whether or not a carbohydrate-restricted telemedically guided weight loss program results in a more pronounced weight loss and influences metabolic risk markers more beneficial than a fat-restricted diet.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes

NCT00608049

Overweight Cardiovascular Diseases

COMPLETED NA

Effects of Whole Grain on Weight Maintenance

NCT01239147

Abdominal Fat Body Weight

COMPLETED PHASE3

Study of Macronutrients and Heart Disease Risk

NCT00609271

Obesity Body Composition Blood Pressure +1 more

COMPLETED NA

Effects of a Wholegrain Diet on Body Composition and Energy Balance

NCT01411540

Overweight Obesity Pre-diabetic

COMPLETED NA

Effects of Meal Macronutrients on Postprandial Lipids

NCT07313787

Nephrotic Syndrome Lipodystrophy Metabolic Syndrome +3 more

NOT_YET_RECRUITING PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

see brief summary.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Obesity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

energy-restricted, CHO-restricted diet

Interventions: carbohydrate restriction of diet: 40% Frequency: daily Duration: 12 months

Group Type EXPERIMENTAL

energy-restricted, CHO-restricted diet

Intervention Type OTHER

carbohydrate content of the diet \< 40% Frequency: daily Duration: 12 months

energy-restricted, CHO-rich diet

Comparator: carbohydrate content of diet: \> 55% Frequency: daily Duration: 12 months

Group Type ACTIVE_COMPARATOR

energy-restricted, CHO-rich diet

Intervention Type OTHER

carbohydrate content of diet \> 55% Frequency: daily Duration: 12 months

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

energy-restricted, CHO-restricted diet

carbohydrate content of the diet \< 40% Frequency: daily Duration: 12 months

Intervention Type OTHER

energy-restricted, CHO-rich diet

carbohydrate content of diet \> 55% Frequency: daily Duration: 12 months

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* age 18-70 years
* body mass index \> 27 kg/m2

Exclusion Criteria

* history of cardiovascular symptomatology
* cholelithiasis
* urolithiasis
* insulin dependent diabetes
* pacemaker implantation
* pregnancy
* lactation
* vegetarianism

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes