Effects of Advanced Glycation Endproducts on Satiety and Inflammation

NCT ID: NCT01434407

Last Updated: 2012-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

19 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2012-03-31

Brief Summary

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The purpose of the meal study is to investigate acute effects on satiety and inflammation of advanced glycation endproducts (AGE) in healthy overweight subjects. The AGE content of the meal is affected by food preparation methods: frying/grilling versus boiling/steaming.

Detailed Description

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Conditions

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Obesity Type 2 Diabetes Insulin Resistance Cardiovascular Disease

Keywords

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Advanced glycation endproducts Satiety Obesity Inflammation Insulin resistance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Low AGE meal

Test meal prepared by boiling/steaming the food

Group Type EXPERIMENTAL

Dietary meal intervention

Intervention Type OTHER

Test meals with different AGE content made by different cooking methods

High AGE meal

Test meal prepared by frying/grilling the food

Group Type EXPERIMENTAL

Dietary meal intervention

Intervention Type OTHER

Test meals with different AGE content made by different cooking methods

Interventions

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Dietary meal intervention

Test meals with different AGE content made by different cooking methods

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy males and females between 20 and 50 years old
* BMI 25-40
* Waist circumference above 88 cm for women and above 102 cm for men

Exclusion Criteria

* Exercise training above 8 hour/week
* Smoking
* Pregnant or breast-feeding women
* Post-menstrual women
* Regular use of medicine (except contraceptive pills)
* Previous gastric bypass surgery
* Donation of blood within the last 3 months
* Involvement in other clinical trials
* Allergic to paraaminobenzoic acid
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Ministry of Science, Technology and Innovation, Denmark

OTHER_GOV

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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AAstrup

Dr Med Sci

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Susanne G Bügel

Role: PRINCIPAL_INVESTIGATOR

Department of Human Nutrition, University of Copenhagen

Locations

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Department of Human Nutrition, University of Copenhagen

Copenhagen, Frederiksberg C, Denmark

Site Status

Countries

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Denmark

References

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Poulsen MW, Bak MJ, Andersen JM, Monosik R, Giraudi-Futin AC, Holst JJ, Nielsen J, Lauritzen L, Larsen LH, Bugel S, Dragsted LO. Effect of dietary advanced glycation end products on postprandial appetite, inflammation, and endothelial activation in healthy overweight individuals. Eur J Nutr. 2014;53(2):661-72. doi: 10.1007/s00394-013-0574-y. Epub 2013 Aug 9.

Reference Type DERIVED
PMID: 23929260 (View on PubMed)

Other Identifiers

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M200

Identifier Type: -

Identifier Source: org_study_id