The Effect of Degree of Rice-polishing on Glycaemic Response

NCT ID: NCT04228341

Last Updated: 2021-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-13

Study Completion Date

2020-06-18

Brief Summary

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To investigate the effects of rice polishing on glycaemic and insulinaemic response in healthy Chinese male volunteers.

Detailed Description

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There will be a total of 8 test session. Each session will last for 3.5 hours. At each test session, volunteers will be served with test meal and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerprick. Following the fasting samples, subject will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

Conditions

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Diabetes Mellitus Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Randomized crossover design
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Glucose Reference 1

Glucose solution 1

Group Type OTHER

Glucose Reference 1

Intervention Type OTHER

50 g of glucose dissolved in 250 ml of water (First glucose control visit)

Glucose Reference 2

Glucose solution 2

Group Type OTHER

Glucose Reference 2

Intervention Type OTHER

50 g of glucose dissolved in 250 ml of water (Second glucose control visit)

Glucose Reference 3

Glucose solution 3

Group Type OTHER

Glucose Reference 3

Intervention Type OTHER

50 g of glucose dissolved in 250 ml of water (Third glucose control visit)

Brown Rice

Cooked brown rice

Group Type EXPERIMENTAL

Brown Rice

Intervention Type OTHER

Unpolished brown rice containing 50 g of available carbohydrate was cooked using a rice cooker (Toyomi) at a ratio of rice to water of 1: 2

3 % polished rice

Cooked 3 % polished rice

Group Type EXPERIMENTAL

3 % polished rice

Intervention Type OTHER

3% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

6 % polished rice

Cooked 6 % polished rice

Group Type EXPERIMENTAL

6 % polished rice

Intervention Type OTHER

6% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

9 % polished rice

9 % polished rice

Group Type EXPERIMENTAL

9 % polished rice

Intervention Type OTHER

9 % polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

20 % Polished rice

Cooked 20 % Polished rice (White Rice)

Group Type EXPERIMENTAL

20 % Polished rice

Intervention Type OTHER

White rice (20% polished rice), containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2.

Interventions

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Glucose Reference 1

50 g of glucose dissolved in 250 ml of water (First glucose control visit)

Intervention Type OTHER

Glucose Reference 2

50 g of glucose dissolved in 250 ml of water (Second glucose control visit)

Intervention Type OTHER

Glucose Reference 3

50 g of glucose dissolved in 250 ml of water (Third glucose control visit)

Intervention Type OTHER

Brown Rice

Unpolished brown rice containing 50 g of available carbohydrate was cooked using a rice cooker (Toyomi) at a ratio of rice to water of 1: 2

Intervention Type OTHER

3 % polished rice

3% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

Intervention Type OTHER

6 % polished rice

6% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

Intervention Type OTHER

9 % polished rice

9 % polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

Intervention Type OTHER

20 % Polished rice

White rice (20% polished rice), containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male
* Chinese ethnicity
* Age ≥21 and ≤ 60 years
* Body mass index between 18.5 to 25 kg/m2
* Normal blood pressure =\<140/90 mmHg
* Fasting blood glucose \<6.0 mmol/L
* In general good health

Exclusion Criteria

* Current smoker
* Have any metabolic diseases (such as diabetes, hypertension etc)
* Do not have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
* Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
* Have intolerances or allergies to any foods
* Currently partake in sports at the competitive and/or endurance levels
* Intentionally restrict food intake
Minimum Eligible Age

21 Years

Maximum Eligible Age

60 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Singapore Institute of Food and Biotechnology Innovation

OTHER_GOV

Sponsor Role lead

Responsible Party

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JeyaKumar Henry

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Clinical Nutrition Research Centre

Singapore, , Singapore

Site Status

Countries

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Singapore

Other Identifiers

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2018/01079

Identifier Type: -

Identifier Source: org_study_id

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