Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia

NCT ID: NCT02654301

Last Updated: 2016-01-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Study Completion Date

2015-02-28

Brief Summary

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The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).

Detailed Description

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In this double-blind crossover designed study, Participants were randomly assigned to consume a sucrose drink (Control, sucrose 50g + deionized water 100g) or a sucrose drink additionally containing 5 g (Test 1, sucrose : xylose = 10:1), 3.33 g (Test 2, sucrose : xylose = 15:1) or 2.5 g (Test 3, sucrose : xylose = 20:1) of D-xylose with a week interval.

Conditions

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Postprandial Hyperglycemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Control group

sucrose drink (Control, sucrose 50g + deionized water 100g)

Group Type PLACEBO_COMPARATOR

Control

Intervention Type DIETARY_SUPPLEMENT

sucrose 50 g + deionized water 100 g

5 g xylose group

5 g xylose (Test 1, sucrose : xylose = 10:1),

Group Type ACTIVE_COMPARATOR

Test 1

Intervention Type DIETARY_SUPPLEMENT

sucrose : xylose = 10:1, sucrose 50 g + xylose 5 g + deionized water 95 g

3.33 g xylose group

3.33 g xylose (Test 2, sucrose : xylose = 15:1)

Group Type ACTIVE_COMPARATOR

Test 2

Intervention Type DIETARY_SUPPLEMENT

sucrose : xylose = 15:1, sucrose 50 g + xylose 3.33 g + deionized water 96.67 g

2.5 g xylose group

2.5 g xylose (Test 3, sucrose : xylose = 20:1)

Group Type ACTIVE_COMPARATOR

Test 3

Intervention Type DIETARY_SUPPLEMENT

sucrose : xylose = 20:1, sucrose 50 g + xylose 2.5 g + deionized water 97.5 g

Interventions

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Test 1

sucrose : xylose = 10:1, sucrose 50 g + xylose 5 g + deionized water 95 g

Intervention Type DIETARY_SUPPLEMENT

Test 2

sucrose : xylose = 15:1, sucrose 50 g + xylose 3.33 g + deionized water 96.67 g

Intervention Type DIETARY_SUPPLEMENT

Test 3

sucrose : xylose = 20:1, sucrose 50 g + xylose 2.5 g + deionized water 97.5 g

Intervention Type DIETARY_SUPPLEMENT

Control

sucrose 50 g + deionized water 100 g

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

1\) healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL)

Exclusion Criteria

1. history of taking an insulin-injection or oral hypoglycemic agents
2. evidence of alcohol abuse or alcoholism
3. pregnancy or breast feeding
4. chronic gastrointestinal disorder
5. seriously abnormal liver or renal function
6. an occupation at risk of death when hypoglycemia occurs
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Jong Ho Lee

Department of Food and Nutrition

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jong Ho Lee, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Laboratory of clinical nutrigenetics/nutrigenomics, Yonsei University

References

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Jun YJ, Lee J, Hwang S, Kwak JH, Ahn HY, Bak YK, Koh J, Lee JH. Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design. Trials. 2016 Mar 15;17(1):139. doi: 10.1186/s13063-016-1261-0.

Reference Type DERIVED
PMID: 26979433 (View on PubMed)

Other Identifiers

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Xylose_2015

Identifier Type: -

Identifier Source: org_study_id

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