Specific Language Impairment (SLI) in Children May Caused by Epileptic Brain Activity
NCT ID: NCT04141332
Last Updated: 2019-10-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
160 participants
OBSERVATIONAL
2018-02-01
2019-03-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Group 1
80 Patient
EEG was recorded by EEG Machines
EEG was recorded by EEG Machines
Group 2
80 Control subject
EEG was recorded by EEG Machines
EEG was recorded by EEG Machines
Interventions
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EEG was recorded by EEG Machines
EEG was recorded by EEG Machines
Eligibility Criteria
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Inclusion Criteria
* 80 healthy children with age and sex match control group.
Exclusion Criteria
* meningitis or encephalitis
* motor weakness
* hearing disorders
* IQ below seventy
* CP, social deprivation
* autism and
* psychiatric disorders .
3 Years
6 Years
ALL
Yes
Sponsors
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Mansoura University Hospital
OTHER
Responsible Party
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Ahmed Esmael
Assistant Prof of Neurology
Principal Investigators
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Esmael M Ahmed, MD
Role: PRINCIPAL_INVESTIGATOR
Assistant Prof of Neurology
Locations
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Mansoura University Hospital
Al Mansurah, Dakahlia Governorate, Egypt
Countries
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References
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Tomas E, Vissers C. Behind the Scenes of Developmental Language Disorder: Time to Call Neuropsychology Back on Stage. Front Hum Neurosci. 2019 Jan 9;12:517. doi: 10.3389/fnhum.2018.00517. eCollection 2018.
2-Kraft, S.J. & De Thorne, L.S. The Brave New World of Epigenetics: Embracing Complexity in the Study of Speech and Language Disorders Current Developmental Disorders Reports . 2014; 1: 207.
3-Hillert, Dieter. Encyclopedia of Evolutionary Psychological Science, Chapter: Neurobiology of Language, Publisher: Springer, Editors Viviana Weekes-Shackelford, Todd K. Shackelford, Viviana A. Weekes-Shackelford. Neurobiology of Language.2016: pp.1-15
Laasonen M, Smolander S, Lahti-Nuuttila P, Leminen M, Lajunen HR, Heinonen K, Pesonen AK, Bailey TM, Pothos EM, Kujala T, Leppanen PHT, Bartlett CW, Geneid A, Lauronen L, Service E, Kunnari S, Arkkila E. Understanding developmental language disorder - the Helsinki longitudinal SLI study (HelSLI): a study protocol. BMC Psychol. 2018 May 21;6(1):24. doi: 10.1186/s40359-018-0222-7.
Ghandour H, Eldin SK, Sallam Y, Mahmoud S. Associated comorbidities of specific language impairment. Benha Med J. 2018; 35:115-21.
Carol Westby. Social-Emotional Outcomes for Children With SLI . Word of Mouth. 2017 ; 28 (4):1-5.
Kim EH, Ko TS. Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes. Korean J Pediatr. 2016 Apr;59(4):155-64. doi: 10.3345/kjp.2016.59.4.155. Epub 2016 Apr 30.
Syam UK, Thomas SV. Epileptiform activity in the electroencephalogram of 6-year-old children of women with epilepsy. Ann Indian Acad Neurol. 2016 Jul-Sep;19(3):318-22. doi: 10.4103/0972-2327.179974.
Holmes GL. What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data? Epileptic Disord. 2014 Oct;16 Spec No 1(Spec No 1):S12-22. doi: 10.1684/epd.2014.0686.
Ung H, Cazares C, Nanivadekar A, Kini L, Wagenaar J, Becker D, Krieger A, Lucas T, Litt B, Davis KA. Interictal epileptiform activity outside the seizure onset zone impacts cognition. Brain. 2017 Aug 1;140(8):2157-2168. doi: 10.1093/brain/awx143.
McTague A, Howell KB, Cross JH, Kurian MA, Scheffer IE. The genetic landscape of the epileptic encephalopathies of infancy and childhood. Lancet Neurol. 2016 Mar;15(3):304-16. doi: 10.1016/S1474-4422(15)00250-1. Epub 2015 Nov 17.
Staley K. Molecular mechanisms of epilepsy. Nat Neurosci. 2015 Mar;18(3):367-72. doi: 10.1038/nn.3947. Epub 2015 Feb 24.
Faught E, Karakis I, Drane DL. The Impact of Interictal Discharges on Performance. Curr Neurol Neurosci Rep. 2018 Oct 8;18(12):88. doi: 10.1007/s11910-018-0892-9.
Luz-Escamilla L, Morales-Gonzalez JA. Association between Interictal Epileptiform Discharges and Autistic Spectrum Disorder. Brain Sci. 2019 Jul 30;9(8):185. doi: 10.3390/brainsci9080185.
Kane N, Acharya J, Benickzy S, Caboclo L, Finnigan S, Kaplan PW, Shibasaki H, Pressler R, van Putten MJAM. A revised glossary of terms most commonly used by clinical electroencephalographers and updated proposal for the report format of the EEG findings. Revision 2017. Clin Neurophysiol Pract. 2017 Aug 4;2:170-185. doi: 10.1016/j.cnp.2017.07.002. eCollection 2017. No abstract available.
Ghacibeh GA, Fields C. Interictal epileptiform activity and autism. Epilepsy Behav. 2015 Jun;47:158-62. doi: 10.1016/j.yebeh.2015.02.025. Epub 2015 Apr 3.
Shweta Singh, Shivani Pandey, Vivek Agarwal. A Comparative study of Vineland Adaptive Behavior Scale II and Vineland Social Maturity Scale on children and adolescents with Intellectual Disability J. Indian Assoc. Child Adolesc. Ment. Health 2019; 15(1):27-38.
El-Maghraby R. Comprehensive Arabic Language test as a tool for assessing delayed language impaired Egyptian children [MD thesis]. Alexandria: Faculty of Medicine, Alexandria University;2008.
Moreno MA. Speech and Language Delays in Young Children. JAMA Pediatr. 2015 Aug;169(8):796. doi: 10.1001/jamapediatrics.2014.2146. No abstract available.
Fadhli, Khadija & Al-Bunaian, Nada. Prevalence and Social Influences of Delayed Language Development in Preschool-Age Saudi Children. International Journal of Science and Research. 2017:6. 6-391.
Wallace IF, Berkman ND, Watson LR, Coyne-Beasley T, Wood CT, Cullen K, Lohr KN. Screening for Speech and Language Delay in Children 5 Years Old and Younger: A Systematic Review. Pediatrics. 2015 Aug;136(2):e448-62. doi: 10.1542/peds.2014-3889. Epub 2015 Jul 7.
Reilly S, Tomblin B, Law J, McKean C, Mensah FK, Morgan A, Goldfeld S, Nicholson JM, Wake M. Specific language impairment: a convenient label for whom? Int J Lang Commun Disord. 2014 Jul-Aug;49(4):416-51. doi: 10.1111/1460-6984.12102.
Kalnak N, Peyrard-Janvid M, Sahlen B, Forssberg H. Family history interview of a broad phenotype in specific language impairment and matched controls. Genes Brain Behav. 2012 Nov;11(8):921-7. doi: 10.1111/j.1601-183X.2012.00841.x. Epub 2012 Sep 20.
Baumer FM, Cardon AL, Porter BE. Language Dysfunction in Pediatric Epilepsy. J Pediatr. 2018 Mar;194:13-21. doi: 10.1016/j.jpeds.2017.10.031. Epub 2017 Dec 11. No abstract available.
Tuchman R. Autism and Cognition Within Epilepsy: Social Matters. Epilepsy Curr. 2015 Jul-Aug;15(4):202-5. doi: 10.5698/1535-7511-15.4.202.
Hamdy M. Bedair, Mona K. Mohamed, Rania M. Abdou, Faten I. El Kafrawy. Concurrent language disorders in children with idiopathic epilepsy. Egyptian Journal of Otolaryngology. 2017: 33 (3): 603-609.
Mehta B, Chawla VK, Parakh M, Parakh P, Bhandari B, Gurjar AS. EEG Abnormalities in Children with Speech and Language Impairment. J Clin Diagn Res. 2015 Jul;9(7):CC04-7. doi: 10.7860/JCDR/2015/13920.6168. Epub 2015 Jul 1.
Jones JE, Siddarth P, Gurbani S, Shields WD, Caplan R. Cognition, academic achievement, language, and psychopathology in pediatric chronic epilepsy: Short-term outcomes. Epilepsy Behav. 2010 Jul;18(3):211-7. doi: 10.1016/j.yebeh.2010.03.015. Epub 2010 May 14.
Sanchez Fernandez I, Loddenkemper T, Galanopoulou AS, Moshe SL. Should epileptiform discharges be treated? Epilepsia. 2015 Oct;56(10):1492-504. doi: 10.1111/epi.13108. Epub 2015 Aug 21.
Parry-Fielder B, Collins K, Fisher J, Keir E, Anderson V, Jacobs R, Scheffer IE, Nolan T. Electroencephalographic abnormalities during sleep in children with developmental speech-language disorders: a case-control study. Dev Med Child Neurol. 2009 Mar;51(3):228-34. doi: 10.1111/j.1469-8749.2008.03163.x. Epub 2009 Jan 29.
Other Identifiers
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Mansoura University Hospital
Identifier Type: -
Identifier Source: org_study_id
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