Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery
NCT ID: NCT01927302
Last Updated: 2021-08-11
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Clinical Phase
NA
Total Enrollment
90 participants
Study Classification
INTERVENTIONAL
Study Start Date
2013-04-30
Study Completion Date
2019-03-27
Brief Summary
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The purpose of this study is to investigate the effects of treatment for specific language deficits in people with aphasia. In addition to language and cognitive measures, changes in brain function will also be gathered before and after the treatment is administered in order to track any changes resulting from receiving treatment.
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Detailed Description
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Naming Impairments (Anomia):
The labs of Dr. Swathi Kiran (Boston University) and Dr. David Caplan (Harvard University, Massachusetts General Hospital) will be studying language recovery in adults with anomia (naming impairments) following a stroke. Participants will receive treatment focusing on the semantic features of common objects (e.g., that birds can fly). The study will examine how naming and other language abilities change in response to treatment, as well as how the brain changes, as measured by magnetic resonance imaging (MRI) and other techniques.
Spelling/Writing Impairments (Dysgraphia):
At Johns Hopkins University, the lab of Dr. Brenda Rapp will investigate the neurobiology of language recovery in individuals with dysgraphia (spelling/writing impairments) resulting from a stroke. In this study, treatment will focus on improving spelling ability. The study will examine how spelling and other language abilities change in response to treatment, as well as how the brain changes, as measured by magnetic resonance imaging (MRI) and other techniques.
Deficits in Sentence Comprehension \& Production:
Dr. Cynthia Thompson's lab at Northwestern University will investigate language recovery in individuals with deficits in sentence production and comprehension. Treatment focuses on production and comprehension of complex sentences. At baseline (week 0) and after the treatment period (at week 12), participants take part in language, eye-tracking, and MRI testing, in order to learn how the processing of language, as well as brain function, changes as a result of treatment.
The labs of Dr. Swathi Kiran (Boston University) and Dr. David Caplan (Harvard University, Massachusetts General Hospital) will be studying language recovery in adults with anomia (naming impairments) following a stroke. Participants will receive treatment focusing on the semantic features of common objects (e.g., that birds can fly). The study will examine how naming and other language abilities change in response to treatment, as well as how the brain changes, as measured by magnetic resonance imaging (MRI) and other techniques.
Spelling/Writing Impairments (Dysgraphia):
At Johns Hopkins University, the lab of Dr. Brenda Rapp will investigate the neurobiology of language recovery in individuals with dysgraphia (spelling/writing impairments) resulting from a stroke. In this study, treatment will focus on improving spelling ability. The study will examine how spelling and other language abilities change in response to treatment, as well as how the brain changes, as measured by magnetic resonance imaging (MRI) and other techniques.
Deficits in Sentence Comprehension \& Production:
Dr. Cynthia Thompson's lab at Northwestern University will investigate language recovery in individuals with deficits in sentence production and comprehension. Treatment focuses on production and comprehension of complex sentences. At baseline (week 0) and after the treatment period (at week 12), participants take part in language, eye-tracking, and MRI testing, in order to learn how the processing of language, as well as brain function, changes as a result of treatment.
Conditions
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Aphasia
Dysgraphia
Anomia
Agrammatism
Stroke
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
NONE
Study Groups
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Naming Deficits
Language treatment will focus on improving naming deficits in people who have aphasia. An experimental group will receive treatment focusing on naming objects and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
Group Type
EXPERIMENTAL
Treatment Focusing on Naming Objects
Intervention Type
BEHAVIORAL
Treatment will be administered from week 0 until week 12.
No Treatment
Intervention Type
BEHAVIORAL
No treatment will be administered.
Spelling and/or Writing Deficits
Language treatment will focus on improving writing and/or spelling deficits in people who have aphasia. An experimental group will receive treatment focusing on improving spelling abilities and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
Group Type
EXPERIMENTAL
Treatment Focusing on Improving Spelling Abilities
Intervention Type
BEHAVIORAL
Treatment will be administered from week 0 until week 12.
No Treatment
Intervention Type
BEHAVIORAL
No treatment will be administered.
Sentence Processing
Language treatment will focus on improving sentence comprehension and production deficits in people who have aphasia. An experimental group will receive treatment focusing on improving sentence processing and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
Group Type
EXPERIMENTAL
Treatment Focusing on Improving Sentence Processing
Intervention Type
BEHAVIORAL
Treatment will be administered from week 0 until week 12.
No Treatment
Intervention Type
BEHAVIORAL
No treatment will be administered.
Interventions
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Treatment Focusing on Naming Objects
Treatment will be administered from week 0 until week 12.
Intervention Type
BEHAVIORAL
Treatment Focusing on Improving Spelling Abilities
Treatment will be administered from week 0 until week 12.
Intervention Type
BEHAVIORAL
Treatment Focusing on Improving Sentence Processing
Treatment will be administered from week 0 until week 12.
Intervention Type
BEHAVIORAL
No Treatment
No treatment will be administered.
Intervention Type
BEHAVIORAL
Other Intervention Names
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Language treatment
Language Treatment
Language Treatment
Eligibility Criteria
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Inclusion Criteria
* Aphasia following a stroke
* Stoke was at least 1 year ago
* Medically stable
* Right-handed
* Normal or 'corrected to normal' vision and hearing
* English as primary language
* At least a high school education
* Stoke was at least 1 year ago
* Medically stable
* Right-handed
* Normal or 'corrected to normal' vision and hearing
* English as primary language
* At least a high school education
Exclusion Criteria
* History of neurological disease, head trauma, psychiatric disorders, alcoholism, or developmental speech, language, or learning disabilities
Minimum Eligible Age
35 Years
Maximum Eligible Age
80 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Sponsor Role
collaborator
National Institutes of Health (NIH)
NIH
Sponsor Role
collaborator
Northwestern University
OTHER
Sponsor Role
lead
Responsible Party
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Cynthia K Thompson
Ralph and Jean Sundin Professor of Communication Sciences
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Cynthia K Thompson, PhD
Role: STUDY_DIRECTOR
Northwestern University
David Caplan, MDCM, PhD
Role: PRINCIPAL_INVESTIGATOR
Harvard University Massachusetts General Hospital
Brenda Rapp, PhD
Role: PRINCIPAL_INVESTIGATOR
Johns Hopkins University
Swathi Kiran, PhD, CCC-SLP
Role: PRINCIPAL_INVESTIGATOR
Boston University
Todd B Parrish, PhD
Role: PRINCIPAL_INVESTIGATOR
Northwestern University
Locations
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Northwestern University
Chicago, Illinois, United States
Site Status
Johns Hopkins University
Baltimore, Maryland, United States
Site Status
Boston University
Boston, Massachusetts, United States
Site Status
Harvard University
Cambridge, Massachusetts, United States
Site Status
Countries
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United States
References
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Walenski M, Europa E, Caplan D, Thompson CK. Neural networks for sentence comprehension and production: An ALE-based meta-analysis of neuroimaging studies. Hum Brain Mapp. 2019 Jun 1;40(8):2275-2304. doi: 10.1002/hbm.24523. Epub 2019 Jan 28.
Reference Type
BACKGROUND
Kiran S, Thompson CK. Neuroplasticity of Language Networks in Aphasia: Advances, Updates, and Future Challenges. Front Neurol. 2019 Apr 2;10:295. doi: 10.3389/fneur.2019.00295. eCollection 2019.
Reference Type
BACKGROUND
Crinion J, Holland AL, Copland DA, Thompson CK, Hillis AE. Neuroimaging in aphasia treatment research: quantifying brain lesions after stroke. Neuroimage. 2013 Jun;73:208-14. doi: 10.1016/j.neuroimage.2012.07.044. Epub 2012 Jul 27.
Reference Type
BACKGROUND
Kiran S, Ansaldo A, Bastiaanse R, Cherney LR, Howard D, Faroqi-Shah Y, Meinzer M, Thompson CK. Neuroimaging in aphasia treatment research: standards for establishing the effects of treatment. Neuroimage. 2013 Aug 1;76:428-35. doi: 10.1016/j.neuroimage.2012.10.011. Epub 2012 Oct 9.
Reference Type
BACKGROUND
Meinzer M, Beeson PM, Cappa S, Crinion J, Kiran S, Saur D, Parrish T, Crosson B, Thompson CK; Neuroimaging in Aphasia Treatment Research Workshop. Neuroimaging in aphasia treatment research: consensus and practical guidelines for data analysis. Neuroimage. 2013 Jun;73:215-24. doi: 10.1016/j.neuroimage.2012.02.058. Epub 2012 Feb 24.
Reference Type
BACKGROUND
Rapp B, Caplan D, Edwards S, Visch-Brink E, Thompson CK. Neuroimaging in aphasia treatment research: issues of experimental design for relating cognitive to neural changes. Neuroimage. 2013 Jun;73:200-7. doi: 10.1016/j.neuroimage.2012.09.007. Epub 2012 Sep 10.
Reference Type
BACKGROUND
Ditges R, Barbieri E, Thompson CK, Weintraub S, Weiller C, Mesulam MM, Kummerer D, Schroter N, Musso M. German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia. Brain Sci. 2021 Apr 8;11(4):474. doi: 10.3390/brainsci11040474.
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BACKGROUND
Thompson CK. Neurocognitive Recovery of Sentence Processing in Aphasia. J Speech Lang Hear Res. 2019 Nov 22;62(11):3947-3972. doi: 10.1044/2019_JSLHR-L-RSNP-19-0219. Epub 2019 Nov 22.
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BACKGROUND
Schuchard J, Thompson CK. Implicit and explicit learning in individuals with agrammatic aphasia. J Psycholinguist Res. 2014 Jun;43(3):209-24. doi: 10.1007/s10936-013-9248-4.
Reference Type
BACKGROUND
Wang H, Yoshida M, Thompson CK. Parallel functional category deficits in clauses and nominal phrases: The case of English agrammatism. J Neurolinguistics. 2014 Jan;27(1):75-102. doi: 10.1016/j.jneuroling.2013.09.001.
Reference Type
BACKGROUND
Thompson CK, Faroqi-Shah Y, & Lee J. (2015). Models of sentence production. In: A. Hillis (Ed.). The handbook of adult language disorders: Integrating cognitive neuropsychology, neurology, and rehabilitation. Second Edition (pp. 328-354). New York: Psychology Press.
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BACKGROUND
Thompson CK, Kielar A. (2014). Neural bases of sentence processing: evidence from neurolinguistic and neuroimaging studies. In M. Goldrick, V. Ferreira, & M. Miozzo (Eds.) The Oxford Handbook of Language Production (pp. 47-69). New York: Oxford University Press.
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BACKGROUND
Thompson CK, Meltzer-Asscher, A. (2014). Neurocognitive mechanisms of verb argument structure processing. In Asaf Bachrach, Isabelle Roy and Linaea Stockall (Eds.) Structuring the Argument: Multidisciplinary research on verb argument structure (pp. 141-168). John Benjamins.
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BACKGROUND
Iorga M, Higgins J, Caplan D, Zinbarg R, Kiran S, Thompson CK, Rapp B, Parrish TB. Predicting language recovery in post-stroke aphasia using behavior and functional MRI. Sci Rep. 2021 Apr 19;11(1):8419. doi: 10.1038/s41598-021-88022-z.
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Ingo C, Sui Y, Chen Y, Parrish TB, Webb AG, Ronen I. Parsimonious continuous time random walk models and kurtosis for diffusion in magnetic resonance of biological tissue. Front Phys. 2015 Mar;3:11. doi: 10.3389/fphy.2015.00011. Epub 2015 Mar 16.
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Meier EL, Johnson JP, Pan Y, Kiran S. The utility of lesion classification in predicting language and treatment outcomes in chronic stroke-induced aphasia. Brain Imaging Behav. 2019 Dec;13(6):1510-1525. doi: 10.1007/s11682-019-00118-3.
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Gilmore N, Meier EL, Johnson JP, Kiran S. Nonlinguistic Cognitive Factors Predict Treatment-Induced Recovery in Chronic Poststroke Aphasia. Arch Phys Med Rehabil. 2019 Jul;100(7):1251-1258. doi: 10.1016/j.apmr.2018.12.024. Epub 2019 Jan 9.
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Meier EL, Johnson JP, Kiran S. Left frontotemporal effective connectivity during semantic feature judgments in patients with chronic aphasia and age-matched healthy controls. Cortex. 2018 Nov;108:173-192. doi: 10.1016/j.cortex.2018.08.006. Epub 2018 Aug 27.
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Meier EL, Johnson JP, Villard S, Kiran S. Does Naming Therapy Make Ordering in a Restaurant Easier? Dynamics of Co-Occurring Change in Cognitive-Linguistic and Functional Communication Skills in Aphasia. Am J Speech Lang Pathol. 2017 May 17;26(2):266-280. doi: 10.1044/2016_AJSLP-16-0028.
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Meier EL, Lo M, Kiran S. Understanding semantic and phonological processing deficits in adults with aphasia: Effects of category and typicality. Aphasiology. 2016;30(6):719-749. doi: 10.1080/02687038.2015.1081137. Epub 2015 Sep 12.
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Kiran S, Meier EL, Kapse KJ, Glynn PA. Changes in task-based effective connectivity in language networks following rehabilitation in post-stroke patients with aphasia. Front Hum Neurosci. 2015 Jun 9;9:316. doi: 10.3389/fnhum.2015.00316. eCollection 2015.
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Breining B, Rapp B. Investigating the mechanisms of written word production: Insights from the written blocked cyclic naming paradigm. Read Writ. 2019 Jan;32(1):65-94. doi: 10.1007/s11145-017-9742-4. Epub 2017 Apr 12.
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Tainturier MJ, Bosse ML, Roberts DJ, Valdois S, Rapp B. Lexical neighborhood effects in pseudoword spelling. Front Psychol. 2013 Nov 28;4:862. doi: 10.3389/fpsyg.2013.00862. eCollection 2013.
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Dufor O, Rapp B. Letter representations in writing: an fMRI adaptation approach. Front Psychol. 2013 Oct 28;4:781. doi: 10.3389/fpsyg.2013.00781. eCollection 2013.
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Rapp B, Damian M. (2018). From thought to action: Producing written language. In, Rueschemeyer, S.A & Gaskell, G. (Eds.) Oxford Handbook of Psycholinguistics. Oxford University Press.
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Nickels L, Kohnen S, Rapp B. (Eds.). (2018). Treatment as a tool for investigating cognition. Psychology Press.
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Rapp B, Purcell J. (2017). Understanding how we produce written words: Lessons from the brain. In, De Zubicaray, G. and Schiller, N.O. (Eds.) Oxford Handbook of Neurolinguistics. Oxford University Press.
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Rapp B, Fischer-Baum S. (2014). Representation of orthographic knowledge. In Ferreira, Goldrick and Miozzo (Eds.) Oxford Handbook on Language Production. Oxford University Press.
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Riley EA, Thompson CK. Training Pseudoword Reading in Acquired Dyslexia: A Phonological Complexity Approach. Aphasiology. 2015 Feb 1;29(2):129-150. doi: 10.1080/02687038.2014.955389.
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BACKGROUND
Lee J, Yoshida M, Thompson CK. Grammatical Planning Units During Real-Time Sentence Production in Speakers With Agrammatic Aphasia and Healthy Speakers. J Speech Lang Hear Res. 2015 Aug;58(4):1182-94. doi: 10.1044/2015_JSLHR-L-14-0250.
Reference Type
BACKGROUND
Wang H, Thompson CK. Assessing Syntactic Deficits in Chinese Broca's aphasia using the Northwestern Assessment of Verbs and Sentences-Chinese (NAVS-C). Aphasiology. 2016;30(7):815-840. doi: 10.1080/02687038.2015.1111995. Epub 2015 Nov 16.
Reference Type
BACKGROUND
Cho-Reyes S, Mack JE, Thompson CK. Grammatical Encoding and Learning in Agrammatic Aphasia: Evidence from Structural Priming. J Mem Lang. 2016 Dec;91:202-218. doi: 10.1016/j.jml.2016.02.004. Epub 2016 Mar 21.
Reference Type
BACKGROUND
Mack JE, Nerantzini M, Thompson CK. Recovery of Sentence Production Processes Following Language Treatment in Aphasia: Evidence from Eyetracking. Front Hum Neurosci. 2017 Mar 13;11:101. doi: 10.3389/fnhum.2017.00101. eCollection 2017.
Reference Type
BACKGROUND
Mack JE, Thompson CK. Recovery of Online Sentence Processing in Aphasia: Eye Movement Changes Resulting From Treatment of Underlying Forms. J Speech Lang Hear Res. 2017 May 24;60(5):1299-1315. doi: 10.1044/2016_JSLHR-L-16-0108.
Reference Type
BACKGROUND
Barbieri E, Mack J, Chiappetta B, Europa E, Thompson CK. Recovery of offline and online sentence processing in aphasia: Language and domain-general network neuroplasticity. Cortex. 2019 Nov;120:394-418. doi: 10.1016/j.cortex.2019.06.015. Epub 2019 Jul 13.
Reference Type
RESULT
Thompson CK, Walenski M, Chen Y, Caplan D, Kiran S, Rapp B, Grunewald K, Nunez M, Zinbarg R, Parrish TB. Intrahemispheric Perfusion in Chronic Stroke-Induced Aphasia. Neural Plast. 2017;2017:2361691. doi: 10.1155/2017/2361691. Epub 2017 Mar 5.
Reference Type
RESULT
Lukic S, Barbieri E, Wang X, Caplan D, Kiran S, Rapp B, Parrish TB, Thompson CK. Right Hemisphere Grey Matter Volume and Language Functions in Stroke Aphasia. Neural Plast. 2017;2017:5601509. doi: 10.1155/2017/5601509. Epub 2017 May 9.
Reference Type
RESULT
Lukic S, Thompson CK, Barbieri E, Chiappetta B, Bonakdarpour B, Kiran S, Rapp B, Parrish TB, Caplan D. Common and distinct neural substrates of sentence production and comprehension. Neuroimage. 2021 Jan 1;224:117374. doi: 10.1016/j.neuroimage.2020.117374. Epub 2020 Sep 17.
Reference Type
RESULT
Higgins J, Barbieri E, Wang X, Mack J, Caplan D, Kiran S, Rapp B, Thompson C, Zinbarg R, Parrish T. Reliability of BOLD signals in chronic stroke-induced aphasia. Eur J Neurosci. 2020 Oct;52(8):3963-3978. doi: 10.1111/ejn.14739. Epub 2020 Apr 28.
Reference Type
RESULT
Europa E, Gitelman DR, Kiran S, Thompson CK. Neural Connectivity in Syntactic Movement Processing. Front Hum Neurosci. 2019 Feb 13;13:27. doi: 10.3389/fnhum.2019.00027. eCollection 2019.
Reference Type
RESULT
Lukic S, Meltzer-Asscher A, Higgins J, Parrish TB, Thompson CK. Neurocognitive correlates of category ambiguous verb processing: The single versus dual lexical entry hypotheses. Brain Lang. 2019 Jul;194:65-76. doi: 10.1016/j.bandl.2019.04.005. Epub 2019 May 16.
Reference Type
RESULT
Hsu CJ, Thompson CK. Manual Versus Automated Narrative Analysis of Agrammatic Production Patterns: The Northwestern Narrative Language Analysis and Computerized Language Analysis. J Speech Lang Hear Res. 2018 Feb 15;61(2):373-385. doi: 10.1044/2017_JSLHR-L-17-0185.
Reference Type
RESULT
Thompson CK. Single subject controlled experiments in aphasia: the science and the state of the science. J Commun Disord. 2006 Jul-Aug;39(4):266-91. doi: 10.1016/j.jcomdis.2006.02.003. Epub 2006 Apr 25.
Reference Type
RESULT
Mack JE, Meltzer-Asscher A, Barbieri E, Thompson CK. Neural correlates of processing passive sentences. Brain Sci. 2013 Aug 2;3(3):1198-214. doi: 10.3390/brainsci3031198.
Reference Type
RESULT
Meltzer-Asscher A, Mack JE, Barbieri E, Thompson CK. How the brain processes different dimensions of argument structure complexity: evidence from fMRI. Brain Lang. 2015 Mar;142:65-75. doi: 10.1016/j.bandl.2014.12.005. Epub 2015 Feb 4.
Reference Type
RESULT
Schuchard J, Nerantzini M, Thompson CK. Implicit learning and implicit treatment outcomes in individuals with aphasia. Aphasiology. 2017;31(1):25-48. doi: 10.1080/02687038.2016.1147526. Epub 2016 Feb 19.
Reference Type
RESULT
Mack JE, Wei AZ, Gutierrez S, Thompson CK. Tracking sentence comprehension: Test-retest reliability in people with aphasia and unimpaired adults. J Neurolinguistics. 2016 Nov;40:98-111. doi: 10.1016/j.jneuroling.2016.06.001. Epub 2016 Jun 24.
Reference Type
RESULT
Schuchard J, Thompson CK. Sequential learning in individuals with agrammatic aphasia: evidence from artificial grammar learning. J Cogn Psychol (Hove). 2017;29(5):521-534. doi: 10.1080/20445911.2017.1293065. Epub 2017 Feb 17.
Reference Type
RESULT
Johnson JP, Meier EL, Pan Y, Kiran S. Treatment-related changes in neural activation vary according to treatment response and extent of spared tissue in patients with chronic aphasia. Cortex. 2019 Dec;121:147-168. doi: 10.1016/j.cortex.2019.08.016. Epub 2019 Sep 19.
Reference Type
DERIVED
Related Links
Access external resources that provide additional context or updates about the study.
http://www.bu.edu/aphasiaresearch/
Boston University's Aphasia Research Laboratory
http://sites.krieger.jhu.edu/cogneuro-lab/
Johns Hopkins University's CogNeuro Research Laboratory
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
P50
Identifier Type: -
Identifier Source: org_study_id
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