Word-Retrieval Treatment for Aphasia: Semantic Feature Analysis

NCT ID: NCT00125242

Last Updated: 2014-12-24

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 110 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2005-07-31
• Study Completion Date: 2013-04-30

Brief Summary

The purpose of this investigation is to further develop and test a treatment for word-finding problems in aphasia. The treatment is designed to strengthen meaning associations within categories of words (e.g., animals, tools, fruits). The treatment is also designed to be used as a search strategy in instances of word-finding difficulty. The study was devised to evaluate the extent to which treatment increases the ability to recall trained, as well as untrained, words.

Detailed Description

The purpose of the proposed research is to examine the effects of a semantically-oriented treatment on word retrieval in persons with aphasia. The planned investigations are designed to further the development of semantic feature training so that it may serve as not only a mechanism for improving disrupted lexical semantic processing, but also as a compensatory strategy during word retrieval failures. The proposed research will also address the issue of exemplar typicality (Kiran & Thompson, 2003) by examining the effects of training typical versus atypical exemplars of various categories with individuals with different types of aphasia. A series of 24 single subject experimental designs will be conducted in the context of a group design to address the following experimental questions:

• Will training atypical examples of living and artifact noun categories using semantic feature training result in a significantly different outcome* than training typical examples of living and artifact noun categories?
• Will training of one category of nouns using semantic feature training result in improved retrieval of untrained categories of nouns?
• Will effects of semantic feature training vary across aphasia types?
• Will semantic feature training result in increased production of content during discourse?
• Will generalization to untrained typical examples vary across generalization lists that are repeatedly exposed and those that are limited in exposure? (i.e., Does repeated exposure appear to contribute to generalization?)

• Outcome measure will reflect acquisition, response generalization within category, and response generalization across category effects of treatment.

Conditions

Aphasia; Language Disorders; Speech Disorders

Keywords

Aphasia; Language therapy; Rehabilitation of speech and language disorders; Speech-language pathology

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Semantic Feature Analysis (SFA)

Word retrieval treatment for aphasia.

Group Type: EXPERIMENTAL

Semantic Feature Analysis (SFA)Training

Intervention Type: BEHAVIORAL

SFA entails having the speech-language pathologist (SLP) guide the participant through generation of pertinent semantic features for pictured treatment items (e.g., category membership, physical description, location of item in context, personal associations, action associated with item). For some participants, treatment items were grouped according to typicality of category membership (e.g,, a robin-typical bird and penguin-atypical bird). Training of atypical items may stimulate a broader semantic activation of the category and thus, may promote greater generalization. Treatment was applied sequentially to sets of items in the context of single-subject, multiple baseline designs. In this way, replication of treatment effects could be evaluated within and across participants. Treatment was administered by certified SLPs three times per week until prescribed accuracy levels were met during nontreatment probes or a maximum number of treatment sessions was completed.

Participants for Stimuli Development

Non-brain-injured participants provided data for development of treatment stimuli.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Semantic Feature Analysis (SFA)Training

SFA entails having the speech-language pathologist (SLP) guide the participant through generation of pertinent semantic features for pictured treatment items (e.g., category membership, physical description, location of item in context, personal associations, action associated with item). For some participants, treatment items were grouped according to typicality of category membership (e.g,, a robin-typical bird and penguin-atypical bird). Training of atypical items may stimulate a broader semantic activation of the category and thus, may promote greater generalization. Treatment was applied sequentially to sets of items in the context of single-subject, multiple baseline designs. In this way, replication of treatment effects could be evaluated within and across participants. Treatment was administered by certified SLPs three times per week until prescribed accuracy levels were met during nontreatment probes or a maximum number of treatment sessions was completed.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Diagnosis of Wernicke's, Broca's, or Conduction aphasia with significant word-retrieval deficits
• At least 6 months post-onset of single, left-hemisphere stroke
• Minimum of high-school education
• Visual and auditory acuity sufficient for experimental tasks
• Nonverbal intelligence within normal limits

Exclusion Criteria

• Diagnosed mental illness other than depression
• Neurological condition other than that which resulted in aphasia
• History of alcohol or substance abuse
• Non-native English speaker
• Premorbid history of speech/language disorder

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

US Department of Veterans Affairs

FED

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Julie L. Wambaugh, PhD

Role: PRINCIPAL_INVESTIGATOR

VA Salt Lake City Health Care System, Salt Lake City

Locations

VA Salt Lake City Health Care System, Salt Lake City

Salt Lake City, Utah, United States

Countries

United States

References

Wambaugh JL, Mauszycki S, Cameron R, Wright S, Nessler C. Semantic feature analysis: incorporating typicality treatment and mediating strategy training to promote generalization. Am J Speech Lang Pathol. 2013 May;22(2):S334-69. doi: 10.1044/1058-0360(2013/12-0070).

Reference Type: RESULT

PMID: 23695909 (View on PubMed)

Wambaugh JL, Mauszycki S, Wright S. Semantic feature analysis: Application to confrontation naming of actions in aphasia. Aphasiology. 2013 Oct 28; 28(1):DOI:10.1080/02687038.2013.845739.

Reference Type: RESULT

Other Identifiers

C3826-R

Identifier Type: -

Identifier Source: org_study_id