Sentence Production Training in Aphasia

NCT ID: NCT05415501

Last Updated: 2024-12-18

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 104 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-08-01
• Study Completion Date: 2026-05-30

Brief Summary

This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which learning conditions are most effective in creating maximal training gains. Then, in a later study, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the studies.

Detailed Description

Over five years, the investigators will conduct a series of studies to develop a novel intervention strategy for improving sentence production and comprehension in persons with aphasia. Specifically, the investigators will use implicit learning of grammar as a novel facilitator for language recovery in aphasia. The planned studies seek to test the hypothesis that implicit learning alters the central language system in PWA, creating lasting and generalized improvements in both sentence production and comprehension. Aim 1 will determine the extent to which different learning conditions modulate immediate and long-term improvement in sentence production. The investigators integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced learning in PWA. In Aim 2, using a set of eyetracking and sentence comprehension tasks, it will be investigated whether the effects of priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine which learning conditions result in greater cross-modality generalization. In Aim 3, the investigators will develop and establish Phase I efficacy data of an implicit priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The project will recruit both individuals with aphasia and without aphasia.

Conditions

Aphasia

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Structural priming training

Participants will be enrolled in 3 sessions of structural priming training (for experiment 1-3) or up to 15 treatment sessions (for experiment 4). Each session will be about 2 hour long, consisting of a set of tasks, including repeating, making, and remembering various types of sentences. In experiment 1-3, each participant will receive two different experimental priming conditions that are being compared within each session. In experiment 4, participants will receive a structural priming treatment in a single-subject design.

Group Type: EXPERIMENTAL

Sentence training

Intervention Type: BEHAVIORAL

Participants will be trained to read, make, and recall sentences during each session.

Interventions

Sentence training

Participants will be trained to read, make, and recall sentences during each session.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Individuals with post-stroke aphasia
• At least 6 months post-onset of eft hemisphere stroke
• Native speaker of English
• Normal or corrected to normal hearing and vision
• High-school educated
• Difficulty communicating in sentences, with some ability to use words independently

Exclusion Criteria

• Severe apraxia of speech
• Other neurological conditions affecting communication (e.g., dementia)
• Uncontrolled psychiatric/psychological conditions affecting thinking and communication
• Active alcohol/substance abuse

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Temple University

OTHER

Sponsor Role: collaborator

University of California, San Diego

OTHER

Sponsor Role: collaborator

Purdue University

OTHER

Sponsor Role: lead

Responsible Party

Ji Yeon Lee

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jiyeon Lee, PhD

Role: PRINCIPAL_INVESTIGATOR

Purdue University

Locations

Purdue University

West Lafayette, Indiana, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Jiyeon Lee, PhD

Role: CONTACT

lee1704@purdue.edu

7654943810

Jiyeon Lee

Role: CONTACT

lee1704@purdue.edu

7654943810

Facility Contacts

Jiyeon Lee

Role: primary

lee1704@purdue.edu

765-494-3810

Other Identifiers

IRB-2021-659

Identifier Type: -

Identifier Source: org_study_id