Mathematically Arterialised Testing of Hypercapnic Subjects Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-15

Study Completion Date

2021-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Prospective observational cohort study of patients admitted to hospital with suspected hypercapnic respiratory failure and requiring treatment with non-invasive ventilation (NIV) as part of standard, routine management. Contemporaneous blood gas samples will be obtained via arterial, capillary, and venous methods. The venous samples will undergo mathematical arterialisation via the v-TAC system. In line with standard medical care, arterial samples will be obtained before starting NIV and at two set points afterwards (day 1 post-NIV, and pre-discharge). Pre-existing clinical thresholds will be used to assess the reliability of v-TAC against ABG, the existing gold standard and will conduct a retrospective model of decision-making once the blood sampling component of the study is concluded.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

ReAcT CO2: A Study to Assess TcCO2 to Guide Acute NIV

NCT05674760

Acute Hypercapnic Respiratory Failure

UNKNOWN NA

Noninvasive Ventilation After Extubation in Hypercapnic Patients

NCT01047852

Respiratory Failure

COMPLETED NA

Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory Failure

NCT01174316

Respiratory Failure Neuromuscular Disease Chest Wall Disorder +2 more

WITHDRAWN NA

Non-invasive Monitoring of Mixed Venous Oxygen Saturation Using the Capnodynamic Method in Adults

NCT06632197

Ventilatory Failure Cardiac Failure Mechanical Ventilation Pressure High

NOT_YET_RECRUITING

Two Modes of Mechanical Ventilation for Intensive Care Patients With Low Blood Oxygen Due to Breathing Difficulties

NCT06140056

Hypoxic Respiratory Failure Ventilators, Mechanical

TERMINATED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hypercapnic Respiratory Failure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Aged 18 years or above.
* Admitted for consideration of home Non Invasive Ventilation.
* Due to undergo arterial blood gas sampling as part of routine clinical care

Exclusion Criteria

* Inability to provide informed consent.
* Clinical necessity to perform blood gas sampling prior to allowing sufficient time for informed consent.
* Inability to obtain reliable SpO2 readings

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No