Evaluation of Prolonged Apnea Supported by High Frequency Non-invasive Ventilation.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-31

Study Completion Date

2022-09-30

Brief Summary

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The purpose of the study is to assess the efficacy of high-frequency non-invasive ventilation on apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung disease.

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Detailed Description

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High frequency ventilation (HF-V) allows to ensure oxygen delivery and carbon dioxide clearance despite the absence of thoracic movement in anesthetized, invasively ventilated subjects. This same technique could be applied by a non-invasive interface (HF-NIV), allowing to obtain a prolonged apnea (absence of thoraco-abdominal respiratory movements) in awaken subjects. Such an application would be of interest for several clinical applications, e.g. lung imaging and radio-therapy treatment on lung cancer. The purpose of the study is to assess the effect of different HF-NIV setting on the apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung diseases.

Conditions

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Non-invasive Ventilation High-frequency Ventilation Healthy Volunteer Lung Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Low - High frequence sequence

High-Frequency non-invasive ventilation (HF-NIV) with 2 different settings, sequence of respiratory rate 250/min and respiratory rate 500/min

Group Type EXPERIMENTAL

High-frequency non-invasive ventilation

Intervention Type DEVICE

Comparison of 2 different settings of HF-NIV

High - Low frequence sequence

High-Frequency non-invasive ventilation (HF-NIV) with 2 different settings, sequence of respiratory rate 500/min and respiratory rate 250/min

Group Type EXPERIMENTAL

High-frequency non-invasive ventilation

Intervention Type DEVICE

Comparison of 2 different settings of HF-NIV

Interventions

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High-frequency non-invasive ventilation

Comparison of 2 different settings of HF-NIV

Intervention Type DEVICE

Other Intervention Names

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HF-NIV

Eligibility Criteria

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Inclusion Criteria

* healthy subjets : normal respiratory function and no known lung disease
* lung disease patients : chronic obstructive pulmonary disease, Sarcoidosis, Cystic fibrosis
* age \>=18y