Tidal Volume in Patients With "de Novo" Acute Hypoxemic Respiratory Failure
NCT ID: NCT04741659
Last Updated: 2021-11-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
21 participants
INTERVENTIONAL
2021-01-20
2021-07-30
Brief Summary
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The aim of this study is evaluate the tidal volume, measured by respiratory inductance plethysmography, in patients receiving different non invasive respiratory support.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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spontaneous breathing trial
the patients will be asked to breathe spontaneously using their actual low oxygen flow
Ventimask
The patients will be asked to breathe spontaneously using their actual low oxygen flow
High Flow Nasal cannula (HFNC)
The patients will be asked to breathe using high flow nasal cannula (HFNC). Air flow will set up to 60 l/m, temperature according to patient's comfort and FiO2 in order to obtain SpO2 values \>/= 92%
Helmet CPAP
The patients will be asked to breathe with Helmet. CPAP will set at 10 cmH2O and FiO2 in order to obtain SpO2 values \>/= 92%
Non Invasive Ventilation (NIV)
the patients will be asked to breathe with the support of a ventilator via a oro-nasal interface
High Flow Nasal cannula (HFNC)
The patients will be asked to breathe with HFNC of 40 L/min
Ventimask
The patients will be asked to breathe spontaneously using their actual low oxygen flow
High Flow Nasal cannula (HFNC)
The patients will be asked to breathe using high flow nasal cannula (HFNC). Air flow will set up to 60 l/m, temperature according to patient's comfort and FiO2 in order to obtain SpO2 values \>/= 92%
Helmet CPAP
The patients will be asked to breathe with Helmet. CPAP will set at 10 cmH2O and FiO2 in order to obtain SpO2 values \>/= 92%
Non Invasive Ventilation (NIV)
the patients will be asked to breathe with the support of a ventilator via a oro-nasal interface
Helmet CPAP
the patients will be asked to breathe with the Helmet CPAP
Ventimask
The patients will be asked to breathe spontaneously using their actual low oxygen flow
High Flow Nasal cannula (HFNC)
The patients will be asked to breathe using high flow nasal cannula (HFNC). Air flow will set up to 60 l/m, temperature according to patient's comfort and FiO2 in order to obtain SpO2 values \>/= 92%
Helmet CPAP
The patients will be asked to breathe with Helmet. CPAP will set at 10 cmH2O and FiO2 in order to obtain SpO2 values \>/= 92%
Non Invasive Ventilation (NIV)
the patients will be asked to breathe with the support of a ventilator via a oro-nasal interface
Non Invasive Ventilation (NIV)
the patients will be asked to breathe with the support of a ventilator via a oro-nasal interface
Ventimask
The patients will be asked to breathe spontaneously using their actual low oxygen flow
High Flow Nasal cannula (HFNC)
The patients will be asked to breathe using high flow nasal cannula (HFNC). Air flow will set up to 60 l/m, temperature according to patient's comfort and FiO2 in order to obtain SpO2 values \>/= 92%
Helmet CPAP
The patients will be asked to breathe with Helmet. CPAP will set at 10 cmH2O and FiO2 in order to obtain SpO2 values \>/= 92%
Non Invasive Ventilation (NIV)
the patients will be asked to breathe with the support of a ventilator via a oro-nasal interface
Interventions
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Ventimask
The patients will be asked to breathe spontaneously using their actual low oxygen flow
High Flow Nasal cannula (HFNC)
The patients will be asked to breathe using high flow nasal cannula (HFNC). Air flow will set up to 60 l/m, temperature according to patient's comfort and FiO2 in order to obtain SpO2 values \>/= 92%
Helmet CPAP
The patients will be asked to breathe with Helmet. CPAP will set at 10 cmH2O and FiO2 in order to obtain SpO2 values \>/= 92%
Non Invasive Ventilation (NIV)
the patients will be asked to breathe with the support of a ventilator via a oro-nasal interface
Eligibility Criteria
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Inclusion Criteria
* Informed consent
* Enrollment within the first 24 hours after ARF
Exclusion Criteria
* Body Mass Index (BMI) \> 30 kg/m2;
* Previous diagnosis of Obstructive sleep apnea syndrome (OSAS)
* Chest wall disease
* Heart failure
* Severe hemodynamic instability ( need for amine support)
* Acute coronary syndrome (ACS)
* Severe arrhythmia
* Patients unable to protect respiratory airways
* Respiratory arrest and need for endotracheal intubation
* Pregnancy
* Need for sedation
* Home long-term oxygen therapy
18 Years
99 Years
ALL
No
Sponsors
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IRCCS Azienda Ospedaliero-Universitaria di Bologna
OTHER
Responsible Party
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dr. Stefano Nava
Stefano Nava, Professor of Respiratory Medicine/ Alma Mater Studiorum University of Bologna (IT)- Director of Respiratory and Critical Care Unit/ S.Orsola-Malpighi University Hospital, Bologna (IT)
Principal Investigators
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Stefano Nava, MD
Role: PRINCIPAL_INVESTIGATOR
Alma Mater Studiorum University of Bologna (IT)- Director of Respiratory and Critical Care Unit/ IRCSS S.Orsola-Malpighi University Hospital, Bologna (IT)
Locations
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IRCCS Policlinico di Sant'Orsola
Bologna, , Italy
Countries
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Other Identifiers
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691/2020/Sper/AOUBo
Identifier Type: -
Identifier Source: org_study_id