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Efects of Noninvasive Mechanical Ventilation and Conventional Mechanical Ventilation in Patients With Severe Comunity Pneumonia

NCT ID: NCT00523497

Last Updated: 2007-08-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Brief Summary

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The purpose of this study is to determine whether the noninvasive ventilation is more effective in the treatment of severe comunity acquired pneumonia in comparison with the conventional mechanical ventilation with orotracheal intubation.

Detailed Description

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Conditions

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Community Acquired Pneumonia. Acute Hypoxemic Respiratory Failure

Keywords

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Severe community-acquired pneumonia Noninvasive mechanical ventilation Acute hypoxemic respiratory failure.

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Interventions

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Non invasive mechanical ventilation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

The criteria for the diagnosis of SCAP included:

* Blood systolic pressure lower than 90 mmHg or blood diastolic pressure lower than 60 mmHg
* RR higher than 30 breaths per minute
* PaO2/FiO2 lower than 250 while breathing through a Venturi mask with a 50% inspired oxygen fraction (FiO2)
* Bilateral or multiple lobar infiltrations evidenced by thorax X-ray, and
* Use of vasopressor drugs

Exclusion Criteria

* COPD
* Asthma
* Acute cardiogenic pulmonary edema
* Severe haemodynamic instability (arterial systolic pressure lower than 70 mmHg) or requirements of vasoactive drugs
* Glasgow score equal to or lower than 9 or requiring OTI for airway protection or for recent pulmonary resucitation
* Antecedents of respiratory failure resulting from neuromuscular pathology
* Failure of two or more organs
* Facial deformities; and
* Recent facial, aesophagic and gastric surgeries
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Privado del Sur

OTHER

Sponsor Role lead

Principal Investigators

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S. A Lasdica, Study Principal Investigator

Role: PRINCIPAL_INVESTIGATOR

Locations

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Hospital Privado del Sur

Bahía Blanca, Buenos Aires, Argentina

Site Status

Countries

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Argentina

Other Identifiers

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NIV67-07

Identifier Type: -

Identifier Source: org_study_id