NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases
NCT ID: NCT06182956
Last Updated: 2023-12-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
18 participants
INTERVENTIONAL
2024-01-01
2026-12-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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NIV + CPAP + HFO
The patient will be placed under noninvasive mechanical ventilation during 30 min, then continuous positive airway pressure during 30 min and then nasal high-flow oxygen during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.
Noninvasive mechanical ventilation
Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.
Nasal high-flow oxygen therapy
Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.
Continuous positive airway pressure
Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.
NIV + HFO + CPAP
The patient will be placed under noninvasive mechanical ventilation during 30 min, then nasal high-flow oxygen during 30 min and then continuous positive airway pressure during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.
Noninvasive mechanical ventilation
Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.
Nasal high-flow oxygen therapy
Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.
Continuous positive airway pressure
Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.
CPAP + NIV + HFO
The patient will be placed under continuous positive airway pressure during 30 min, then noninvasive mechanical ventilation during 30 min and then nasal high-flow oxygen during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.
Noninvasive mechanical ventilation
Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.
Nasal high-flow oxygen therapy
Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.
Continuous positive airway pressure
Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.
CPAP + HFO + NIV
The patient will be placed under continuous positive airway pressure during 30 min, then nasal high-flow oxygen during 30 min and then noninvasive mechanical ventilation during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.
Noninvasive mechanical ventilation
Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.
Nasal high-flow oxygen therapy
Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.
Continuous positive airway pressure
Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.
HFO + CPAP + NIV
The patient will be placed under nasal high-flow oxygen during 30 min, then continuous positive airway pressure during 30 min and then noninvasive mechanical ventilation during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.
Noninvasive mechanical ventilation
Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.
Nasal high-flow oxygen therapy
Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.
Continuous positive airway pressure
Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.
HFO + NIV + CPAP
The patient will be placed under nasal high-flow oxygen during 30 min, then noninvasive mechanical ventilation during 30 min and then continuous positive airway pressure during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.
Noninvasive mechanical ventilation
Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.
Nasal high-flow oxygen therapy
Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.
Continuous positive airway pressure
Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.
Interventions
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Noninvasive mechanical ventilation
Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.
Nasal high-flow oxygen therapy
Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.
Continuous positive airway pressure
Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.
Eligibility Criteria
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Inclusion Criteria
* Hospitalization in intensive care unit
* Acute exacerbation of a previously/presently documented diffuse (fibrotic) interstitial lung disease
* Dyspnea majoration since at least 1 month
* Alveolar or ground-glass opacities on CT-scan that are superposed to interstitial lung disease and not explained by left heart failure or volume overload
* Hypoxemia requiring oxygen flows \> 6 L/min
Exclusion Criteria
* Immediate indication to endotracheal intubation or hemodynamic assistance
* Body mass index \> 40
* Presence of a pacemaker or an implantable defibrillator
* Presence of cutaneous lesions where Pulmovista® belt should be placed
* Moribund patient
* Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception
* Protected adult patient (tutorship or curatorship)
* Patient deprived of liberty by court or administrative decision
* No possibility to install nasogastric tube
* Endotracheal or tracheostomy tube requirement during the study
* Hemodynamic assistance requirement during the study
18 Years
ALL
No
Sponsors
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ADIR Association
OTHER
Responsible Party
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Principal Investigators
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Elise ARTAUD-MACARI, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Rouen
Locations
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ADIR Association
Rouen, , France
Countries
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Central Contacts
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Facility Contacts
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Elise ARTAUD-MACARI, MD
Role: primary
Other Identifiers
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IRAPIDPhysio
Identifier Type: -
Identifier Source: org_study_id