High Flow Oxygen Therapy Effect on Healthy Subjects

NCT ID: NCT06086769

Last Updated: 2023-10-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-01

Study Completion Date

2022-06-30

Brief Summary

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The use of high-flow nasal cannula (HFNC) has increased. Diaphragmatic ultrasonography is a tool that, as a noninvasive complement to esophageal pressure (Pes) measurement, allows the evaluation of diaphragm function and reflects, through the diaphragm thickening fraction (DTf), the magnitude of diaphragmatic fiber recruitment. The objective of this study was to evaluate the impact of HFNC therapy on the DTf in healthy subjects. Second, this study aimed to assess the behavior of the respiratory rate (RR) and the work of breathing in these subjects.

Detailed Description

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Conditions

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Healthy Volunteers Diaphragm Respiratory Rate

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Interventions

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High flow nasal canula

Measurement of diaphragm thickening fraction, respiratory rate and esophageal pressure swing with calculation of diaphragmatic pressure-time product without the use of HFNC and with the use of HFNC at 20 and 40 Liters per minute

Intervention Type DEVICE

Other Intervention Names

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diaphragm thickening fraction esophageal pressure swing Respiratory rate

Eligibility Criteria

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Inclusion Criteria

* healthy subjects over 18 years old

Exclusion Criteria

* contraindication for esophageal balloon placement
* diagnosis of lung disease
* smokers
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Argentinian Intensive Care Society

OTHER

Sponsor Role lead

Responsible Party

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Gustavo Plotnikow

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gustavo A Plotnikow, RT

Role: STUDY_CHAIR

Hospital Británico de Buenos Aires

Locations

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Hospital Britanico de Buenos Aires

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Site Status

Countries

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Argentina

Other Identifiers

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CRIHB #1220 PRISA No. 6256

Identifier Type: -

Identifier Source: org_study_id

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