MRI of the Chest Under High Frequency Ventilation

NCT ID: NCT02973373

Last Updated: 2020-03-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-11-30
• Study Completion Date: 2017-07-31

Brief Summary

The purpose of the study is to evaluate the benefit on image quality of MRI of the chest performed under high frequency non-invasive ventilation. This technique indeed allows to generate an apnea duration of several minutes with acquisitions performed at full inspiration. This study will be applied on healthy subjects.

Detailed Description

High frequency ventilation (HF-V) has been applied by using a non-invasive interface allowing to obtain a prolonged apnea in awaken subjects. Such an application should be of interest for MRI taking into account its susceptibility to motion of the chest and the imperfect techniques of respiratory gating that are usually performed at end expiration. The purpose of this study is to assess the benefit on image quality of different sequences performed with and without the device in healthy subjects.

Conditions

Non-invasive Ventilation; High-frequency Ventilation; Healthy Volunteer

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

MRI with HF-NIV

Intervention: Acquisition of MRI with High-Frequency non-invasive ventilation (HF-NIV)

Group Type: EXPERIMENTAL

MRI with High-frequency non-invasive ventilation

Intervention Type: DEVICE

MRI performed under high-frequency non-invasive ventilation

MRI without HF-NIV

Intervention: MRI without High-Frequency non-invasive ventilation (HF-NIV)

Group Type: ACTIVE_COMPARATOR

MRI without High-frequency non-invasive ventilation

Intervention Type: OTHER

MRI performed without High-frequency non-invasive ventilation

Interventions

MRI with High-frequency non-invasive ventilation

MRI performed under high-frequency non-invasive ventilation

Intervention Type: DEVICE

MRI without High-frequency non-invasive ventilation

MRI performed without High-frequency non-invasive ventilation

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy subjets : normal respiratory function and no known lung disease
• Age >=18y

Exclusion Criteria

• Pregnancy

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Lausanne Hospitals

OTHER

Sponsor Role: lead

Responsible Party

Beigelman-Aubry Catherine

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Catherine I Beigelman-Aubry, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospitals Lausanne Switzerland

Locations

University Hospitals

Lausanne, , Switzerland

Countries

Switzerland

References

Delacoste J, Dournes G, Dunet V, Ogna A, Noirez L, Simons J, Long O, Berchier G, Stuber M, Lovis A, Beigelman-Aubry C. Ultrashort echo time imaging of the lungs under high-frequency noninvasive ventilation: A new approach to lung imaging. J Magn Reson Imaging. 2019 Dec;50(6):1789-1797. doi: 10.1002/jmri.26808. Epub 2019 May 28.

Reference Type: RESULT

PMID: 31136048 (View on PubMed)

Other Identifiers

MR-HFV

Identifier Type: -

Identifier Source: org_study_id