Tomodensitometric Study of Pulmonary Effects of Intrapulmonary Percussive Ventilation in ARDS Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-07-31

Study Completion Date

2015-12-31

Brief Summary

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The study is intended to elucidate the pulmonary effects of Intrapulmonary Percussive Ventilation (IPV) with VDR4 ventilator of patients with ARDS, using computed tomography (CT).

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Detailed Description

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Prospective clinical study in ICU of ventilated patients with ARDS. The morphologic pulmonary effects of IPV with VDR4 are not known to the investigators' knowledge.

The main aim is to quantify recruited, normally aerated and overinflated parts of the lungs after a 1 hour treatment with IPV.

Patients with ARDS (focal and non focal) consecutively admitted to the investigators' ICU are enrolled after informed consent.

Patients are intubated and ventilated with Servo-I (GE) and ventilation is optimized according to ARDS-network recommandations.

A first thoracic CT-scan is performed with ICU ventilator and then the patient is ventilated with VDR4 during 1 hour.

A second thoracic CT-scan is then performed and the patient re-ventilated with ICU ventilator.

Arterial blood gases and hemodynamic parameters are recorded during experiments.

CT-scan are analysed and compared for normally aerated, overinflated and recruited lung parenchyma. Regions are determined thanks to their Hounsfield units (HU).

Conditions

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ARDS

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ARDS patients

Group Type EXPERIMENTAL

VDR4 ventilator (Intrapulmonary Percussive Ventilation)

Intervention Type DEVICE

CT scan

Intervention Type DEVICE

Servo-i

Intervention Type DEVICE

- Intubation

Intervention Type DEVICE

Ventilation ( with an ICU conventional ventilator)

Intervention Type DEVICE

Interventions

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VDR4 ventilator (Intrapulmonary Percussive Ventilation)

Intervention Type DEVICE

CT scan

Intervention Type DEVICE

Servo-i

Intervention Type DEVICE

- Intubation

Intervention Type DEVICE

Ventilation ( with an ICU conventional ventilator)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients ventilated more than 48 h
* Sedated patients
* ARDS moderate or severe (Berlin 2012)
* Patients who have given their consent or his family
* Patients aged between 18 and 85 years