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The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance

NCT ID: NCT03341572

Last Updated: 2017-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-11-13

Study Completion Date

2017-12-30

Brief Summary

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To observe the effect of PEEP on CVP among patients with different respiratory compliance

Detailed Description

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30 patients with mechanical ventilation and inserted central venous line will be entered. After gathering demographic data, patients undergone 5,10 and 15cmH2O PEEPs and the respective CVPs of the mentioned points will be recorded. According to the change of CVP, the patients will be divided into high response group and low response group, then comparing the lung compliance and thorax elastic resistance differences between the two groups.

Conditions

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Sepsis ARDS Traumatic Brain Injury

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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high response group

patients undergo 5,10 and 15cmH2O positive end expiratory pressure ,the change of central venous pressure is more than 2.5cmH2O

Group Type EXPERIMENTAL

5,10 and 15cmH2O positive end expiratory pressure

Intervention Type OTHER

every patients undergo 5,10 and 15cmH2O positive end expiratory pressure,and observe the central venous pressure of the mentioned points

low response group

the change of CVP is less than 2.5cmH2O

Group Type PLACEBO_COMPARATOR

5,10 and 15cmH2O positive end expiratory pressure

Intervention Type OTHER

every patients undergo 5,10 and 15cmH2O positive end expiratory pressure,and observe the central venous pressure of the mentioned points

Interventions

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5,10 and 15cmH2O positive end expiratory pressure

every patients undergo 5,10 and 15cmH2O positive end expiratory pressure,and observe the central venous pressure of the mentioned points

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1\. Patients with mechanical ventilation and inserted central venous line

Exclusion Criteria

1. The age is less than 18 years old or more than 80 years old；
2. Pregnant and lying-in woman；
3. Patients undergoing fluid resuscitation and the speed is more than 200ml/h；
4. Patients with norepinephrine dose are greater than 15 micro per minute；
5. Patients with pericarditis、pulmonary heart disease、right heart failure、atrial fibrillation；
6. Patients with COPD(endogenous PEEP is more than 2cmH2O)、tension pneumonthorax、acute episode asthma
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jingyuan,Xu

OTHER

Sponsor Role lead

Responsible Party

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Jingyuan,Xu

Attending doctor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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yi yang, doctor

Role: STUDY_CHAIR

Zhongda Hospital

Locations

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Zhongda Hospital

Nanjing, Jiangsu, China

Site Status RECRUITING

Countries

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China

Central Contacts

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chenglong liang, master

Role: CONTACT

Phone: 15261893562

Email: [email protected]

yi yang, doctor

Role: CONTACT

Phone: +8602583262550

Email: [email protected]

Facility Contacts

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chenglong liang, master

Role: primary

yi yang, doctor

Role: backup

Other Identifiers

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2017ZDSYLL094-P01

Identifier Type: -

Identifier Source: org_study_id