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Different PEEP Settings of COVID-19 Induced ARDS

NCT ID: NCT04359251

Last Updated: 2020-04-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-03-05

Study Completion Date

2020-03-25

Brief Summary

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This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2\<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

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Detailed Description

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After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Conditions

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COVID-19 Mechanical Ventilation Pressure High Acute Respiratory Distress Syndrome

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Optimizing oxygenation

Best oxygenation during PEEP titration

Group Type EXPERIMENTAL

Gas exchanges at different PEEP

Intervention Type OTHER

Gas exchanges measurement at different PEEP

Optimizing compliance

Best compliance during PEEP titration

Group Type EXPERIMENTAL

lung mechanics at different PEEP

Intervention Type OTHER

lung mechanics measurement at different PEEP

ARDSnet

PEEP settings according to ARDSnet table

Group Type EXPERIMENTAL

Hemodynamics changes at different PEEP

Intervention Type OTHER

Hemodynamics changes measurement at different PEEP

Interventions

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Gas exchanges at different PEEP

Gas exchanges measurement at different PEEP

Intervention Type OTHER

lung mechanics at different PEEP

lung mechanics measurement at different PEEP

Intervention Type OTHER

Hemodynamics changes at different PEEP

Hemodynamics changes measurement at different PEEP

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* COVID-19 patients with mechanical ventilation
* PO2/FIO2\<300mmHg
* ages\>18 years

Exclusion Criteria

* pneumothorax
* pregnant
* hemodynamics is unstable
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Southeast University, China

OTHER

Sponsor Role lead

Responsible Party

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Chun Pan

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Chun C Pan

Role: STUDY_DIRECTOR

Zhongda hospital, Southeast University, Jiangsu, China

Locations

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Zhongda Hospital, Southeast University

Nanjing, Jiangsu, China

Site Status

Countries

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China

References

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Pan C, Lu C, She X, Ren H, Wei H, Xu L, Huang Y, Xia J, Yu Y, Chen L, Du B, Qiu H. Evaluation of Positive End-Expiratory Pressure Strategies in Patients With Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome. Front Med (Lausanne). 2021 Jul 20;8:637747. doi: 10.3389/fmed.2021.637747. eCollection 2021.

Reference Type DERIVED
PMID: 34355001 (View on PubMed)

Other Identifiers

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COVID-19 PEEP titration

Identifier Type: -

Identifier Source: org_study_id

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