Awaken Prone Positioning Ventinlation in COVID-19 Patients
NCT ID: NCT05677984
Last Updated: 2023-09-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
409 participants
INTERVENTIONAL
2023-01-11
2023-05-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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APP group
Directive APP for a target of 12 hours per day or more
Awaken prone positioning ventilation
patients were mandated to keep a prone position for at least 12 hours.
Control group
No intervention on APP
No interventions assigned to this group
Interventions
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Awaken prone positioning ventilation
patients were mandated to keep a prone position for at least 12 hours.
Eligibility Criteria
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Inclusion Criteria
* Severe COVID-19 pneumonia (with typical radiographic alternations) and non-intubated patients.
* SpO2 \<= 93% with ambient air at rest.
* PaO2/FiO2 \<= 300 mmHg
Exclusion Criteria
* morbidity obesity, BMI \> 40
* consciousness disorder (GCS \< 13), delirium dementia
* hemodynamic instability (with norepinephrine \>20 ug/min )
* NYHA Grade III or IV
* Severe hemoptysis
* long term home oxygenation of CPAP
* Refuse invasive mechanical ventilation (DNI DNR)
18 Years
85 Years
ALL
No
Sponsors
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Southeast University, China
OTHER
Responsible Party
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Ling Liu
Professor
Principal Investigators
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Haibo QIU, Dr
Role: STUDY_DIRECTOR
Southeast University
Locations
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Southeast University
Nanjing, Jiangsu, China
Countries
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References
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Sun Q, Zhang R, Zhang J, Xie J, Huang Y, Yang Y, Qiu H, Liu L, Chen H; Chi-ARDS Net (Chinese ARDS Research Network). Impact of awake prone positioning duration on intubation or mortality in COVID-19 patients with acute respiratory failure: secondary analysis of a randomized clinical trial. Ann Intensive Care. 2025 Jun 23;15(1):84. doi: 10.1186/s13613-025-01501-8.
Liu L, Sun Q, Zhao H, Liu W, Pu X, Han J, Yu J, Jin J, Chao Y, Wang S, Liu Y, Wu B, Zhu Y, Li Y, Chang W, Chen T, Xie J, Yang Y, Qiu H, Slutsky A; Chi-ARDS Net (Chinese ARDS Research Network). Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial. Intensive Care Med. 2024 Aug;50(8):1298-1309. doi: 10.1007/s00134-024-07545-x. Epub 2024 Aug 1.
Other Identifiers
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20221227
Identifier Type: -
Identifier Source: org_study_id
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