A Prospective Observational Cohort Study of Awake Prone Position Ventilation Strategy in Patients With Acute Respiratory Failure

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-10

Study Completion Date

2025-09-09

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Awake prone positioning has been used widely for patients with COVID-19.Many research results are not uniform on the key issue of whether the prognosis of patients can be improved，and most of the subjects were patients with SARS-CoV-2 infected who are not intubated.The investigators will conduct a prospective observational study on patients with acute respiratory failure induced by various causes to determine whether awake prone position can reduce the need to upgrade to invasive mechanical ventilation and improve the prognosis of patients compared with standard treatment.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Changes in Lung Aeration and Inspiratory Effort With and Without Awake Prone

NCT05719103

Respiratory Distress Syndrome Ventilation Therapy; Complications

RECRUITING NA

Timed Awake Prone and Repositioning for Patients With Covid-19-induced Hypoxic Respiratory Failure.

NCT05689216

Corona Virus Infection Hypoxic Respiratory Failure

UNKNOWN NA

Awake Prone Positioning in Moderate to Severe COVID-19

NCT05083130

COVID-19 SARS-CoV2 Infection COVID-19 Acute Respiratory Distress Syndrome +2 more

COMPLETED NA

Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure

NCT05866289

Survival, Prosthesis Oxygen Deficiency

COMPLETED

Prone Positioning in Non-intubated Patients With COVID-19 Associated Acute Respiratory Failure

NCT04477655

Covid19

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Respiratory Failure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Awake prone position Group

Patients in awake prone position will be included.

No interventions assigned to this group

Non awake prone position Group

Patients in non awake prone position will be included.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 1.Older than 17 years, admitted to the ICU;2.Patients with acute respiratory failure meet the following conditions：①Under the condition of breathing air at rest, PaO2 of subjects is lower than 60mmHg and/or PaCO2 is higher than 50mmHg; ②Under the support of COT and HFNC, PaO2/FiO2 of the subject is less than 250; ③ Under the support of NIV ;

Exclusion Criteria

* 1.Refusing to cooperate with active treatment; 2.Immediate need for intubation as determined by the treating team.3Patients with hemodynamic instability and moderate to high dose of vasopressors (norepinephrine dose ≥ 0.15 mcg/kg/min)；4.Contraindication to PP (e.g. vomiting, abdominal wound, unstable pelvic/spinal lesions, pregnancy \>20/40 gestation, severe brain injury)；

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No