Prediction of Extubation Failure: A Multicenter Prospective Observational Study

NCT ID: NCT05069441

Last Updated: 2023-02-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

2604 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-15

Study Completion Date

2024-12-31

Brief Summary

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The investigators intend to collect several variables to predict extubation failure among patients who successfully complete a spontaneous breathing trial, and then develop a scale using simple bedside indicators to predict extubation failure.

Detailed Description

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Mechanically ventilated patients who successfully completed a spontaneous breathing trial and prepared for extubation are eligible to enroll in this study. The vital signs, arterial blood gas tests, cough strength, cuff leak test, use of noninvasive ventilation et al. are collected. Patients are followed up to postextubation 28-day or discharge. Extubation failure is defined as reintubatin or death within postextubation 7 days. First, we will analyze the data to predict extubation failure. Then, we will combine several easily obtained variables to develop and validate a scale to predict extubation failure. Finally, we explore the predictive power of extubation failure tested by the scale and find the cutoff value to distinguish the low, moderate and high risk of extubation failure.

Conditions

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Mechanical Ventilation

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with extubation after a weaning trial

Patients who sucessfully complete a spontaneous breathing trial are enrolled in this group.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Prepared for extubation through spontaneous breathing trial;Oral or nasal endotracheal intubation; be at least 18 years old

Exclusion Criteria

* Extubation without a spontaneous breathing trial ;Reintubation due to secondary surgery; Tracheotomy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chongqing Medical University

OTHER

Sponsor Role lead

Responsible Party

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Duan jun

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jun Duan

Role: PRINCIPAL_INVESTIGATOR

First Affiliated Hospital of Chongqing Medical University

Locations

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The First Affiliated Hospital of Chongqing Medical University

Chongqing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Jun Duan, Dr

Role: CONTACT

Linfu Bai, Dr

Role: CONTACT

Facility Contacts

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Jun Duan, Dr

Role: primary

Linfu Bai

Role: backup

Other Identifiers

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ChongqingMU4

Identifier Type: -

Identifier Source: org_study_id

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