Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-02

Study Completion Date

2019-12-31

Brief Summary

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This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.

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Detailed Description

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Conditions

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Acute Respiratory Distress Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Arms A

Strategy 1 - Washout period - Strategy 2

Group Type EXPERIMENTAL

Strategy 1

Intervention Type OTHER

PEEP titration according to transpulmonary-end-expiratory pressure

Strategy 2

Intervention Type OTHER

PEEP titration according to chest wall elastance measurement

Arms B

Strategy 2 - Washout period - Strategy 1

Group Type EXPERIMENTAL

Strategy 1

Intervention Type OTHER

PEEP titration according to transpulmonary-end-expiratory pressure

Strategy 2

Intervention Type OTHER

PEEP titration according to chest wall elastance measurement

Interventions

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Strategy 1

PEEP titration according to transpulmonary-end-expiratory pressure

Intervention Type OTHER

Strategy 2

PEEP titration according to chest wall elastance measurement

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age\> 18 years
* Moderate or severe ARDS
* Consent to participation obtained from a relative

Exclusion Criteria

* Protect adult
* Pregnant or breastfeeding woman
* No-affiliation to the social security scheme
* Contra-indication to the placement of an esophageal pressure measuring catheter
* Pneumothorax
* Hemodynamic and / or respiratory instability
* Extra-corporeal membrane oxygenation

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No