Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
NCT ID: NCT00188058
Last Updated: 2019-03-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
768 participants
INTERVENTIONAL
2002-09-30
2006-02-28
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients
NCT03281473
Variable Pressure Support Trial
NCT01769053
Comparaison of Two Prone Position Techniques on Occurence of Pressure Sores in ICU
NCT05894291
The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics
NCT07188038
Early Spontaneous Breathing in Acute Respiratory Distress Syndrome
NCT01862016
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Minimal alveolar distension
PEEP is set for a total PEEP (PEEP + intrinsic PEEP) between 5 and 9 cm H2O
Setting of positive end-expiratory pressure
Maximal alveolar distension
PEEP is set for a plateau pressure between 28 and 30 cm H20
Setting of positive end-expiratory pressure
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Setting of positive end-expiratory pressure
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Bilateral infiltrates consistent with pulmonary edema
* PaO2/FiO2 \< 300 mmHg
* No clinical evidence of left atrial hypertension. If measured, pulmonary artery occlusion pressure \< 18 mmHg
* Criteria 1, 2 et 3 jointly present for less than 48 hours
* Written informed consent obtained from the patient or surrogate
Exclusion Criteria
* Pregnancy
* Expected duration of mechanical ventilation through an endotracheal tube \< 48 hours
* Participation in other trials within the previous 30 days
* Increased intracranial pressure
* Severe chronic respiratory disease
* Morbid obesity (weight \> 1kg/cm)
* Sickle cell disease
* Bone marrow transplant or chemotherapy-induced neutropenia
* Extended burns (\> 30 % total body surface area)
* Severe chronic liver disease (Child-Pugh score C)
* Pneumothorax
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Ministry of Health, France
OTHER_GOV
University Hospital, Angers
OTHER_GOV
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
ALAIN MERCAT, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Angers
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
General Hospital of Aix en Provence
Aix-en-Provence, , France
South Hospital of Amiens
Amiens, , France
University Hospital of Amiens
Amiens, , France
University Hospital of Angers
Angers, , France
University Hospital of Angers
Angers, , France
Victor Dupouy Hospital
Argenteuil, , France
General Hospital of Arras
Arras, , France
Robert Ballanger Hospital
Aulnay-sous-Bois, , France
General Hospital of Avignon
Avignon, , France
Hospital of Beauvais
Beauvais, , France
Saint André Hospital
Bordeaux, , France
University Hospital of Bordeaux
Bordeaux, , France
Cavale Blanche Hospital
Brest, , France
Hospital of Brive
Brivé, , France
Henri Mondor Hospital
Créteil, , France
Hospital of Dax
Dax, , France
Hospital of Dieppe
Dieppe, , France
Departemental Hospital
La Roche-sur-Yon, , France
Jacques Monod Hospital
Le Havre, , France
Le Kremlin Bicetre Hospital
Le Kremlin-Bicêtre, , France
Docteur Schaffner Hospital
Lens, , France
University Hospital of Claude Huriez
Lille, , France
Croix Rousse Hospital
Lyon, , France
Bon Secours Hospital
Metz, , France
Saint Eloi Hospital
Montpellier, , France
Hospital of Nancy
Nancy, , France
University Hospital of Hotel Dieu
Nantes, , France
University Hospital of Nimes
Nîmes, , France
University Hospital of Nimes
Nîmes, , France
Oloron Sainte Marie Hospital
Oloron-Sainte-Marie, , France
Regional Hospital of Orleans
Orléans, , France
Bichat Claude Bernard Hospital
Paris, , France
University Hospital of Hôtel Dieu
Paris, , France
Hospital Group of Pitié - Salpêtrière
Paris, , France
Hospital group of Pitié-Salpêtrière
Paris, , France
European Hospital of Georges Pompidou
Paris, , France
University Hospital of Jean Bernard
Poitiers, , France
University Hospital of La Milètrie
Poitiers, , France
René Dubos Hospital
Pontoise, , France
Charles Nicolle Hospital
Rouen, , France
University Hospital of Rouen
Rouen, , France
Saint Aubin Les Elbeuf Hospital
Saint-Aubin-lès-Elbeuf, , France
University Hospital of Bellevue
Saint-Etienne, , France
Hospital of Soissons
Soissons, , France
Hautepierre Hospital
Strasbourg, , France
Gustave Dron Hospital
Tourcoing, , France
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Mercat A, Richard J, Brochard L. Comparison of two strategies for setting Peep in ALI/ARDS : EsPress Study.Intensive care med, 19th ESICM Annual Congress - Barcelona, Spain, 2006 Sep, Oral presentation 0365
Diehl JL, Coolen N, Faisy C, Osman D, Prat G, Sebbane M, Nieszkowska A, Gervais C, Richard JC, Richecoeur J, Brochard L, Mercat A, Guerot E, Borgel D. Growth-arrest-specific 6 (GAS6) protein in ARDS patients: determination of plasma levels and influence of PEEP setting. Respir Care. 2013 Nov;58(11):1886-91. doi: 10.4187/respcare.02129. Epub 2013 Apr 9.
Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, Lefrant JY, Prat G, Richecoeur J, Nieszkowska A, Gervais C, Baudot J, Bouadma L, Brochard L; Expiratory Pressure (Express) Study Group. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008 Feb 13;299(6):646-55. doi: 10.1001/jama.299.6.646.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
DGS : 2002 - 0381
Identifier Type: -
Identifier Source: secondary_id
PHRC 01 - 02
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.