Noninvasive Positive Pressure Ventilation in Moderate Acute Respiratory Distress Syndrome
NCT ID: NCT01585922
Last Updated: 2018-11-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
120 participants
INTERVENTIONAL
2012-07-31
2016-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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NPPV
Use the NPPV to treat moderate ARDS
noninvasive positive pressure ventilation (NPPV)
Use NPPV to treat the ARDS patients,and we choose the NPPV ventilators in which the FiO2 can be fixed, for example: the BiPAP Vision or V60 of Phillip Respironics.
IMV
Use invasive mechanical ventilation in treating the patients allocated to this group.
invasive mechanical ventilation
Intubate and give invasive mechanical ventilation to the other group patients when they are allocated at once.
Interventions
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noninvasive positive pressure ventilation (NPPV)
Use NPPV to treat the ARDS patients,and we choose the NPPV ventilators in which the FiO2 can be fixed, for example: the BiPAP Vision or V60 of Phillip Respironics.
invasive mechanical ventilation
Intubate and give invasive mechanical ventilation to the other group patients when they are allocated at once.
Eligibility Criteria
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Inclusion Criteria
2. a clinical presentation of respiratory distress
3. arterial oxygen tension/inspired oxygen fraction (PaO2/FiO2) between 200 mmHg to 300 mmHg. The arterial oxygen tension will be measured in fifteen minutes after NPPV (CPAP 5 cmH2O) was used to the patients stably
4. presence of bilateral pulmonary infiltrate on chest radiograph
5. no evidence of left heart failure as assessed by echocardiography and/or a pulmonary artery wedge pressure( PAWP) \< 18 mmHg
Exclusion Criteria
2. PaCO2 \> 50mmHg
3. Glasgow Coma Scale (GCS)\< 11
4. Upper airway/facial deformity or injury
5. pneumothorax or pneumomediastinum
6. unable to spontaneously clear secretions from their airway
7. respiratory arrest
8. severe ventricular arrhythmia or active myocardial ischemia
9. severe organ dysfunction (including gastrointestinal hemorrhage, disseminated intravascular coagulation, hepatic and renal dysfunction, SOFA score \> 1)
10. severe chronic lung diseases(COPD, Asthma or ILD, et al)
11. end-stage patients who are expected to survive less than six months
12. severe abdominal distension
13. refuse to receive NPPV
14. unable to cooperate with NPPV
18 Years
70 Years
ALL
No
Sponsors
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Beijing Hospital
OTHER_GOV
Responsible Party
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Chen Wang
Vice President
Locations
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Beijing Institute of Respiratory Medicine, Beijing Hospital
Beijing, Beijing Municipality, China
Countries
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References
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Sun B, He H, Wang Z, Qu J, Li X, Ban C, Wan J, Cao B, Tong Z, Wang C. Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study. Crit Care. 2014 Aug 12;18(4):456. doi: 10.1186/s13054-014-0456-6.
Other Identifiers
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20120418BIRM
Identifier Type: -
Identifier Source: org_study_id
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