Invasive Ventilation for Neonates With Acute Respiratory Distress Syndrome(ARDS)
NCT ID: NCT03591796
Last Updated: 2025-07-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
386 participants
INTERVENTIONAL
2024-12-31
2024-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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HFOV
Ventilated infants were randomized to HFOV.
HFOV
Ventilated infants were randomized to HFOV
CMV
Ventilated infants were randomized to CMV.
CMV
Ventilated infants were randomized to CMV.
Interventions
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HFOV
Ventilated infants were randomized to HFOV
CMV
Ventilated infants were randomized to CMV.
Eligibility Criteria
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Inclusion Criteria
* Assisted with CMV within 12 h after birth;
* Diagnosis with ARDS;
* Stabilization for 2 hours before randomization: FiO2 0.40, mean airway pressure (MAP) 10-14 cmH2O, ≤ 40 bpm of respiratory rate, 90%-94% of SpO2, pH \> 7.20, PaCO2 60 mmHg and \> 35% of hematocrit
Exclusion Criteria
* Major congenital anomalies or chromosomal abnormalities;
* Upper respiratory tract abnormalities;
* need for surgery before randomization;
* Grade Ⅲ-IV-intraventricular hemorrhage (IVH).
1 Minute
12 Hours
ALL
No
Sponsors
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Children's Hospital of Chongqing Medical University
OTHER
Jiulongpo No.1 People's Hospital
OTHER
Chongqing Maternal and Child Health Hospital
OTHER
The First Affiliated Hospital of Anhui Medical University
OTHER
Children's Hospital of The Capital Institute of Pediatrics
OTHER
Peking University Third Hospital
OTHER
First Hospital of Tsinghua University
OTHER
Women and Children's Hospital, Branch of Chongqing Sanxia Central Hospital
OTHER
First Affiliated Hospital of Chongqing Medical University
OTHER
Quanzhou Children's Hospital
OTHER
Xiamen Maternity & Child Care Hospital
OTHER
Zhujiang Hospital
OTHER
Guangdong Academy of Medical Science and General Hospital
OTHER
Guangdong Women and Children Hospital
OTHER
Women and Children's Health Hospital of Yulin
OTHER
Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
OTHER
Second Affiliated Hospital of Guangzhou Medical University
OTHER
Guiyang Maternal and Child Health Care Hospital
OTHER
The First People's Hospital of Zunyi
OTHER
Lanzhou University Second Hospital
OTHER
Gansu Provincial Maternal and Child Health Care Hospital
OTHER
LanZhou University
OTHER
First Affiliated Hospital of Harbin Medical University
OTHER
First Affiliated Hospital of Xinjiang Medical University
OTHER
Zhengzhou Children's Hospital, China
OTHER
Third Affiliated Hospital of Zhengzhou University
OTHER
the Maternal and Child Health Hospital of Hainan Province
OTHER
Bethune International Peace Hospital
OTHER
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
OTHER
Children's Hospital of Nanjing Medical University
OTHER
The First Hospital of Jilin University
OTHER
Children's Hospital of Fudan University
OTHER
Maternal and Children's Healthcare Hospital of Taian
OTHER
The Second Hospital of Shandong University
OTHER
Shanxi Provincial Maternity and Children's Hospital
OTHER
Chengdu Women and Children's Center Hospital
OTHER
The Affiliated Hospital Of Southwest Medical University
OTHER
Affiliated Hospital of Southwest Medical University
OTHER
Shenzhen People's Hospital, The Second Medical College of Jinan University
OTHER
Tianjin Central Hospital of Gynecology Obstetrics
OTHER
People's Hospital of Xinjiang Uygur Autonomous Region
OTHER
Kunming Children's Hospital
OTHER
The First People's Hospital of Yunnan
OTHER
First Affiliated Hospital of Kunming Medical University
OTHER
Yan'an Affiliated Hospital of Kunming Medical University
OTHER
Women and Children's Health Hospital of Qujing
OTHER
The People's Hospital of Dehong Autonomous Prefecture
OTHER
The First People's Hospital of Yinchuan
OTHER
The Children's Hospital of Zhejiang University School of Medicine
OTHER
Women's Hospital School Of Medicine Zhejiang University
OTHER
Beijing 302 Hospital
OTHER
Hunan Children's Hospital
OTHER_GOV
Women and Children Hospital of Qinghai Province
OTHER
Jiangxi Province Children's Hospital
OTHER
Inner Mongolia People's Hospital
OTHER
Mianyang Central Hospital
OTHER
People's Liberation Army No.202 Hospital
OTHER
Ningbo Women & Children's Hospital
OTHER
Shanghai Children's Medical Center
OTHER
First Affiliated Hospital of Guangxi Medical University
OTHER
Nanjing Medical University
OTHER
Qinhuangdao Maternal and Child Health Care Hospital
OTHER
Xuzhou Children Hospital
OTHER
The First Affiliated Hospital of Zhengzhou University
OTHER
Xianyang Children's Hospital
OTHER
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
OTHER
Responsible Party
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Chen Long,MD
Principal Investigator
Locations
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Children's Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
Countries
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Other Identifiers
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invasive ventilation for ARDS
Identifier Type: -
Identifier Source: org_study_id
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