Gas Exchange and CT Effects of PEEP in ARDS

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-01

Study Completion Date

2014-08-01

Brief Summary

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The study aims to investigate the association between effects of PEEP on gas exchange model parameters and CT scan results

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ENROLLING_BY_INVITATION PHASE2/PHASE3

Detailed Description

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In ARDS patients on mechanical ventilation, we will compare model-based estimation of gas exchange parameters (shunt, ventilation/perfusion mismatch) with CT-based estimation of effects of low and high PEEP

Conditions

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ARDS

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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ALPE-TAC

ARDS patients on mechanical ventilation. Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O to evaluate potential for recruitment and measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O

Group Type EXPERIMENTAL

ALPE

Intervention Type DIAGNOSTIC_TEST

Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O Measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O

Interventions

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ALPE

Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O Measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

\- ARDS patients requiring mechanical ventilation

Exclusion Criteria

* \<18 years old
* Requirement of extracorporal life support
* Hemodynamic instability
* Barotrauma

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Mauro Panigada

Does a bedside method for describing functional gas exchange compare well with anatomical description via CT scans, and could it predict the effects of recruitment and ventilation/perfusion mismatch improvement.

Responsibility Role PRINCIPAL_INVESTIGATOR