Running Title: PPAR-γ, RXR-α, and VDR Expressions in Periodontitis
NCT ID: NCT04018144
Last Updated: 2019-07-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
45 participants
OBSERVATIONAL
2019-08-01
2020-03-01
Brief Summary
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Methods: Group-1; healthy individuals, Group-2; periodontitis patients-stage 3 grade B, (H-GradeB), Group-3; periodontitis patients-stage 3 grade C, (D-GradeC). Clinical parameters as plaque index (PI), gingival index (GI) and clinical attachment levels (CAL) were measured. Fibroblast and inflammatory cells, PPAR-γ, RXR-α, and VDR levels were determined in histological slides.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Group-1
Healthy individuals
Gingiva Biopsy Sampling
Gingival samples of healthy individuals were collected by gingivectomy or crown lengthening procedure in the routine treatment protocol or before orthodontically indicated tooth extraction. Gingival samples of periodontitis patients were obtained during the scaling and root planning procedure. Posterior maxillary teeth (#4, #5, #6, and #7) were chosen for gingival sampling.
Group-2
Periodontitis patients-stage 3-grade B
Gingiva Biopsy Sampling
Gingival samples of healthy individuals were collected by gingivectomy or crown lengthening procedure in the routine treatment protocol or before orthodontically indicated tooth extraction. Gingival samples of periodontitis patients were obtained during the scaling and root planning procedure. Posterior maxillary teeth (#4, #5, #6, and #7) were chosen for gingival sampling.
Group-3
Periodontitis patients-stage 3-grade C
Gingiva Biopsy Sampling
Gingival samples of healthy individuals were collected by gingivectomy or crown lengthening procedure in the routine treatment protocol or before orthodontically indicated tooth extraction. Gingival samples of periodontitis patients were obtained during the scaling and root planning procedure. Posterior maxillary teeth (#4, #5, #6, and #7) were chosen for gingival sampling.
Interventions
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Gingiva Biopsy Sampling
Gingival samples of healthy individuals were collected by gingivectomy or crown lengthening procedure in the routine treatment protocol or before orthodontically indicated tooth extraction. Gingival samples of periodontitis patients were obtained during the scaling and root planning procedure. Posterior maxillary teeth (#4, #5, #6, and #7) were chosen for gingival sampling.
Eligibility Criteria
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Inclusion Criteria
* no drug use
* no previous periodontal treatment within six months
* no tobacco use
Exclusion Criteria
* patients used antibiotics in the last 6 months
ALL
Yes
Sponsors
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Tokat Gaziosmanpasa University
OTHER
Responsible Party
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Özkan Karataş
Assistant Professor
Locations
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Gaziosmanpasa University
Tokat Province, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Gaziosmanpasa University Per
Identifier Type: -
Identifier Source: org_study_id
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