Variation in Rate of Orthodontic Tooth Movement in Response to Platelet Rich Plasma Therapy

NCT ID: NCT04016727

Last Updated: 2020-01-22

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE4
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-07-02
• Study Completion Date: 2020-02-02

Brief Summary

PRP from 5 ml blood was prepared and 60 units were injected into the buccal vestibule of patient before initiating canine retraction using NiTi coil spring. Pre and post cervical, incisal and mid distances were measured using Vernier calliper.

Detailed Description

Platelet rich plasma was prepared using patients own blood. The production of PRP began with a 6-mL homologous blood sample that was withdrawn from the donor via venupuncture. One milliliter of the blood sample was set apart to determine the concentration of platelets and leukocytes in whole blood. The remaining 5 mL was mixed with an anticoagulant (3.8%, 1-mL sodium citrate) to prevent clotting. The blood sample was centrifuged at 113 g for 5 minutes to separate the plasma containing the platelets from the red cells. The plasma was drawn off the top and centrifuged for an additional 2 minutes at 3772 g to separate the platelets. Suitable platelet concentrations were achieved by the resuspension of PRP with plasma (high platelet concentration, 5 times the concentration in whole blood).

Conditions

Tooth Movement

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: SINGLE

Study Groups

PRP group

patients in which 60 units of prp was injected

Group Type: EXPERIMENTAL

platelet rich plasma

Intervention Type: BIOLOGICAL

Platelet rich plasma was prepared using patients own blood. 60 units of PRP was injected on one side of the arch using insulin syringe. Each patient served as his/her own control (the side with PRP injected) and experimental group (the side without PRP injected). Whether the right or left side served as control or experimental was determined by lottery method. Patients were recalled after 4 weeks and the measurements were repeated again between lateral incisors and canines at mid, cervical and incisal of the teeth and their mean was recorded.

Control group

patients not given any intervention

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

platelet rich plasma

Platelet rich plasma was prepared using patients own blood. 60 units of PRP was injected on one side of the arch using insulin syringe. Each patient served as his/her own control (the side with PRP injected) and experimental group (the side without PRP injected). Whether the right or left side served as control or experimental was determined by lottery method. Patients were recalled after 4 weeks and the measurements were repeated again between lateral incisors and canines at mid, cervical and incisal of the teeth and their mean was recorded.

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• patients requiring first premolar extractions

Exclusion Criteria

• patients taking any drugs, steroids, NSAIDs and antibiotics
• patients with any co morbid conditions

• Minimum Eligible Age: 11 Years
• Maximum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Armed Forces Institute of Dentistry, Pakistan

OTHER

Sponsor Role: lead

Responsible Party

Fatima Hamid

principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

sana tariq, BDS

Role: STUDY_CHAIR

AFID rawalpindi

Locations

AFID

Rawalpindi, Punjab Province, Pakistan

Countries

Pakistan

Other Identifiers

platelet rich plasma

Identifier Type: -

Identifier Source: org_study_id