Contribution of Functional MRI in Assessment of Auditory Processing Disorders
NCT ID: NCT03887182
Last Updated: 2023-03-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
45 participants
INTERVENTIONAL
2020-09-01
2023-12-31
Brief Summary
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Investigators will compare the f-MRI results between three groups of children in order to find specific radiological markers of APD :
* group 1 : children diagnosed with an Auditory Processing Disorder (APD)
* group 2 : children suspect of APD
* group 3 : children without APD (controls)
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Detailed Description
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* Targeted behavioral assessment auditory processing disorder (APD): speech-in-noise perception, phonemic identification and discrimination, dichotic listening test, temporal processing tests, Random Gap Detection Threshold (RGDT) test.
* Psychometric assessment: assessment of visual / auditory working memory, visual / auditory attention, study of cognitive functions.
* Ear, Nose, Throat (ENT) examination with otoscopy, tonal and vocal audiometry and ABR recording.
* Genetic analysis
* Cortical auditory evoked potential (AEP) recording, compared with the automatized cortical AEP recording on Hear Lab machine.
The purpose of the study is looking for objective biomarkers of APD:
* Compare EEG results with MRI-fMRI results
* Analyze the cortical maturation of children who are fitted with hearings aids: second record of cortical APD performed one year after the fitting.
* Compare the results after one year between group 1 ( with or without hearing aids) and children from group 2.
* MRI-fMRI : to analyze the flow of perfusion, the DTI sequences, and the blood oxygen level-dependent (BOLD) effect (fMRI)
With this multidisciplinary evaluation, the investigators wish to improve the diagnosis of APD in suspected children by associating clinical, radiological, electro-physiological and genetic criteria.
Better understanding and more accurate diagnosis of APD's will improve the care management of these children.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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confirmed auditory processing disorders
functional MRI, Cortical Brainstem Auditory Evoked Potential, Genetic
functional MRI
Additional sequence (DTI) and functional MRI (fMRI) during the MRI which is done as part of the usual care
Automated Cortical Brainstem Auditory Evoked Potential
Automated Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG
whole exome sequencing
A study of all the DNA-encoding exons of the child/parent from a sample taken as part of the usual care
suspected not confirmed auditory processing disorders
functional MRI, Cortical Brainstem Auditory Evoked Potential, Genetic
functional MRI
Additional sequence (DTI) and functional MRI (fMRI) during the MRI which is done as part of the usual care
Automated Cortical Brainstem Auditory Evoked Potential
Automated Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG
healthy volunteers
functional MRI, Cortical Brainstem Auditory Evoked Potential, Genetic, multidisciplinary consultation
functional MRI
Additional sequence (DTI) and functional MRI (fMRI) during the MRI which is done as part of the usual care
Automated Cortical Brainstem Auditory Evoked Potential
Automated Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG
Standard Cortical Brainstem Auditory Evoked Potential
Standard Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG
multidisciplinary consultation
multidisciplinary consultation is composed of:
* an ENT consultation and audiometry
* a speech therapy assessment
* a psychometric evaluation
Interventions
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functional MRI
Additional sequence (DTI) and functional MRI (fMRI) during the MRI which is done as part of the usual care
Automated Cortical Brainstem Auditory Evoked Potential
Automated Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG
whole exome sequencing
A study of all the DNA-encoding exons of the child/parent from a sample taken as part of the usual care
Standard Cortical Brainstem Auditory Evoked Potential
Standard Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG
multidisciplinary consultation
multidisciplinary consultation is composed of:
* an ENT consultation and audiometry
* a speech therapy assessment
* a psychometric evaluation
Eligibility Criteria
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Inclusion Criteria
* selected following multidisciplinary consultation whether the diagnosis is confirmed (group G1) or not (group G2).
* Signed consent of both parents
* Affiliated with a health insurance plan
* 7 to 18 years old
* do not present any known hearing pathology
* Signed consent of both parents
* Affiliated with a health insurance plan
Exclusion Criteria
* Contraindication to MRI
* Hearing aids for more than three months prior to inclusion in the study
* Require sedation specifically for research
7 Years
18 Years
ALL
Yes
Sponsors
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Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Isabelle Rouillon, MD, PhD
Role: STUDY_DIRECTOR
Assistance Publique - Hôpitaux de Paris
Locations
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Necker Hospital
Paris, , France
Countries
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References
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Chermak GD, Bamiou DE, Vivian Iliadou V, Musiek FE. Practical guidelines to minimise language and cognitive confounds in the diagnosis of CAPD: a brief tutorial. Int J Audiol. 2017 Jul;56(7):499-506. doi: 10.1080/14992027.2017.1284351. Epub 2017 Feb 28.
Moore DR, Ferguson MA, Edmondson-Jones AM, Ratib S, Riley A. Nature of auditory processing disorder in children. Pediatrics. 2010 Aug;126(2):e382-90. doi: 10.1542/peds.2009-2826. Epub 2010 Jul 26.
Barker MD, Kuruvilla-Mathew A, Purdy SC. Cortical Auditory-Evoked Potential and Behavioral Evidence for Differences in Auditory Processing between Good and Poor Readers. J Am Acad Audiol. 2017 Jun;28(6):534-545. doi: 10.3766/jaaa.16054.
Tomlin D, Rance G. Maturation of the Central Auditory Nervous System in Children with Auditory Processing Disorder. Semin Hear. 2016 Feb;37(1):74-83. doi: 10.1055/s-0035-1570328.
Sharma M, Purdy SC, Kelly AS. Comorbidity of auditory processing, language, and reading disorders. J Speech Lang Hear Res. 2009 Jun;52(3):706-22. doi: 10.1044/1092-4388(2008/07-0226). Epub 2008 Dec 8.
de Wit E, Visser-Bochane MI, Steenbergen B, van Dijk P, van der Schans CP, Luinge MR. Characteristics of Auditory Processing Disorders: A Systematic Review. J Speech Lang Hear Res. 2016 Apr 1;59(2):384-413. doi: 10.1044/2015_JSLHR-H-15-0118.
Demanez L, Dony-Closon B, Lhonneux-Ledoux E, Demanez JP. Central auditory processing assessment: a French-speaking battery. Acta Otorhinolaryngol Belg. 2003;57(4):275-90.
Sharma A, Kraus N, McGee TJ, Nicol TG. Developmental changes in P1 and N1 central auditory responses elicited by consonant-vowel syllables. Electroencephalogr Clin Neurophysiol. 1997 Nov;104(6):540-5. doi: 10.1016/s0168-5597(97)00050-6.
Sharma A, Dorman MF, Spahr AJ. Rapid development of cortical auditory evoked potentials after early cochlear implantation. Neuroreport. 2002 Jul 19;13(10):1365-8. doi: 10.1097/00001756-200207190-00030.
Sharma A, Martin K, Roland P, Bauer P, Sweeney MH, Gilley P, Dorman M. P1 latency as a biomarker for central auditory development in children with hearing impairment. J Am Acad Audiol. 2005 Sep;16(8):564-73. doi: 10.3766/jaaa.16.8.5.
Sharma A, Glick H, Campbell J, Biever A. CENTRAL AUDTIORY DEVELOPMENT IN CHILDREN WITH HEARING LOSS: CLINICAL RELEVANCE OF THE P1 CAEP BIOMARKER IN HEARING-IMPAIRED CHILDREN WITH MULTIPLE DISABILITIES. Hearing Balance Commun. 2013 Sep;11(3):10.3109/21695717.2013.812378. doi: 10.3109/21695717.2013.812378.
Sharma M, Purdy S C, Kelly A S. The contribution of speech-evoked cortical auditory evoked potentials to the diagnosis and measurement of intervention outcomes in children with auditory processing disorder. Semin Hear. 2014;35(1):51-64
Purdy SC, Kelly AS, Davies MG. Auditory brainstem response, middle latency response, and late cortical evoked potentials in children with learning disabilities. J Am Acad Audiol. 2002 Jul-Aug;13(7):367-82.
Anderson S, Chandrasekaran B, Yi HG, Kraus N. Cortical-evoked potentials reflect speech-in-noise perception in children. Eur J Neurosci. 2010 Oct;32(8):1407-13. doi: 10.1111/j.1460-9568.2010.07409.x.
Cunningham J, Nicol T, Zecker S, Kraus N. Speech-evoked neurophysiologic responses in children with learning problems: development and behavioral correlates of perception. Ear Hear. 2000 Dec;21(6):554-68. doi: 10.1097/00003446-200012000-00003.
Punch S, Van Dun B, King A, Carter L, Pearce W. Clinical Experience of Using Cortical Auditory Evoked Potentials in the Treatment of Infant Hearing Loss in Australia. Semin Hear. 2016 Feb;37(1):36-52. doi: 10.1055/s-0035-1570331.
Martin BA, Tremblay KL, Korczak P. Speech evoked potentials: from the laboratory to the clinic. Ear Hear. 2008 Jun;29(3):285-313. doi: 10.1097/AUD.0b013e3181662c0e.
Micallef LA. Auditory Processing Disorder (APD): Progress in Diagnostics So Far. A Mini-Review on Imaging Techniques. J Int Adv Otol. 2015 Dec;11(3):257-61. doi: 10.5152/iao.2015.1009.
Owen JP, Marco EJ, Desai S, Fourie E, Harris J, Hill SS, Arnett AB, Mukherjee P. Abnormal white matter microstructure in children with sensory processing disorders. Neuroimage Clin. 2013 Jun 23;2:844-53. doi: 10.1016/j.nicl.2013.06.009. eCollection 2013.
Kim MJ, Jeon HA, Lee KM, Son YD, Kim YB, Cho ZH. Neuroimaging features in a case of developmental central auditory processing disorder. J Neurol Sci. 2009 Feb 15;277(1-2):176-80. doi: 10.1016/j.jns.2008.10.020. Epub 2008 Dec 6.
Belin P, Zatorre RJ, Lafaille P, Ahad P, Pike B. Voice-selective areas in human auditory cortex. Nature. 2000 Jan 20;403(6767):309-12. doi: 10.1038/35002078.
Thomsen T, Rimol LM, Ersland L, Hugdahl K. Dichotic listening reveals functional specificity in prefrontal cortex: an fMRI study. Neuroimage. 2004 Jan;21(1):211-8. doi: 10.1016/j.neuroimage.2003.08.039.
Pluta A, Wolak T, Czajka N, Lewandowska M, Ciesla K, Rusiniak M, Grudzien D, Skarzynski H. Reduced resting-state brain activity in the default mode network in children with (central) auditory processing disorders. Behav Brain Funct. 2014 Sep 26;10(1):33. doi: 10.1186/1744-9081-10-33.
Bartel-Friedrich S, Broecker Y, Knoergen M, Koesling S. Development of fMRI tests for children with central auditory processing disorders. In Vivo. 2010 Mar-Apr;24(2):201-9.
Other Identifiers
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2018-A03239
Identifier Type: OTHER
Identifier Source: secondary_id
APHP180679
Identifier Type: -
Identifier Source: org_study_id
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