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MR Scanning of Very Young Children With Severe Developmental Disorders

NCT ID: NCT00156221

Last Updated: 2005-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Study Classification

OBSERVATIONAL

Study Start Date

2000-09-30

Study Completion Date

2005-09-30

Brief Summary

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The specific is to study the MR morphologic and spectroscopic brain correlates and predictors of development in children with severe developmental disorders (autistic spectrum disorders and/or mental retardation and/or language disorders). Given the frequently observed association of autism with known medical conditions, particularly in cases with comorbid mental retardation and in cases with atypical autism (Rutter et al., 1994; Gillberg, 1995), children with suspected autism or related developmental disorders will be asked to participate in an extensive state of the art laboratory work-up which includes T1 and T2 weighted MRI of the brain. MRI data will be analyzed both qualitatively, looking for focal abnormalities and degree of myelination, and quantitatively, measuring volumes of total brain, cerebellum, ventricles and grey and white matter. For research purposes, the work-up will be supplied with proton Magnetic Resonance Spectroscopy (MRS) of the brain. This data set provides the opportunity to chart brain-behavior relationships in young children with suspected autism and related PDD cross-sectionally.

Detailed Description

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Conditions

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Autism Mental Retardation Language Disorder

Keywords

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Autism MRI Developmental Disorders

Study Design

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Observational Model Type

NATURAL_HISTORY

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Age 18 months to 7 years
* Diagnosis of autism spectrum disorder, a language disorder or mental retardation

Exclusion Criteria

* Significant motor or sensory impairment
* Major physical abnormalities
* History of serious head injury
* Identifiable neurologic disorder
* Metal implants
* Contraindication for MRI
Minimum Eligible Age

18 Months

Maximum Eligible Age

7 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Netherlands Organisation for Scientific Research

OTHER_GOV

Sponsor Role collaborator

The Dutch Brain Foundation

OTHER

Sponsor Role collaborator

UMC Utrecht

OTHER

Sponsor Role lead

Principal Investigators

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Herman van Engeland, PhD, MD

Role: STUDY_CHAIR

UMC Utrecht

Mijke Zeegers, Msc

Role: PRINCIPAL_INVESTIGATOR

UMC Utrecht

Locations

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UMC Utrecht

Utrecht, , Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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METC UMC Utrecht 99/184

Identifier Type: -

Identifier Source: org_study_id