Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
NCT ID: NCT04070937
Last Updated: 2021-08-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
40 participants
OBSERVATIONAL
2019-09-01
2026-10-30
Brief Summary
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The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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study group
all patients at least 18 years of age who present bilateral vestibulopathy on vestibular investigations according to the Barany criteria
vestibular test 1
videonystagmography
vestibular test 2
video head impulse test
vestibular evoked myogenic potentials
vestibular evoked myogenic potentials to measure the function of otolith organs
audiometry
tonal liminar audiometric thresholds
CT and MR imaging of temporal bone
Ct and MR imaging of temporal bone
p.P51S mutation
analysis of presence of p.P51S mutation in COCH
control group
DFNA9 patients carrying the p.P51S mutation in COCH gene presenting bilateral vestibulopathy according to the Barany criteria
vestibular test 1
videonystagmography
vestibular test 2
video head impulse test
vestibular evoked myogenic potentials
vestibular evoked myogenic potentials to measure the function of otolith organs
audiometry
tonal liminar audiometric thresholds
CT and MR imaging of temporal bone
Ct and MR imaging of temporal bone
p.P51S mutation
analysis of presence of p.P51S mutation in COCH
Interventions
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vestibular test 1
videonystagmography
vestibular test 2
video head impulse test
vestibular evoked myogenic potentials
vestibular evoked myogenic potentials to measure the function of otolith organs
audiometry
tonal liminar audiometric thresholds
CT and MR imaging of temporal bone
Ct and MR imaging of temporal bone
p.P51S mutation
analysis of presence of p.P51S mutation in COCH
Eligibility Criteria
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Inclusion Criteria
* reduced caloric response6 (sum of bither- mal max. peak SPV on each side \<6◦/sec7) and/or
* reduced horizontal angular VOR gain \<0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50◦ /sec) and a phase lead \>68 degrees (time constant \<5 sec).
* must be 18 or older
Exclusion Criteria
* does not meet Barany criteria for BV
* contraindication for CT and MR imaging
18 Years
90 Years
ALL
No
Sponsors
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Jessa Hospital
OTHER
Responsible Party
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Sebastien Janssens de Varebeke
principal investigator
Locations
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Jessa Hospital
Hasselt, Limburg, Belgium
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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JessaH-4
Identifier Type: -
Identifier Source: org_study_id
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