Four Ways to Be Dizzy: When Physiology Fails to Explain Disability Insights From the UVIS International Survey

NCT ID: NCT07297355

Last Updated: 2025-12-22

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 250 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-11-10
• Study Completion Date: 2025-08-03

Brief Summary

The aim of this international study is to better understand how vestibular disorders affect daily life, including physical balance, vision and movement tolerance, emotional wellbeing, and cognitive functioning. Vestibular disorders are common but often difficult to diagnose because symptoms vary widely from one patient to another. To improve clinical care, we need large-scale information on the real-world experience of patients across different countries and clinical settings.

The UCLouvain Vertigo International Survey (UVIS) collects standardized information from adults with confirmed vestibular disorders, including questionnaires about dizziness-related handicap, emotional symptoms, and cognitive-vestibular complaints. Ear-nose-throat (ENT) specialists also provide routine clinical test results, such as caloric testing, vestibular evoked myogenic potentials (cVEMP and oVEMP), video head impulse tests (vHIT), and posturography. By combining these data, the study aims to identify different patient profiles and to examine how subjective symptoms relate to the physiological function of the vestibular system.

Participants take part during their routine clinical visit. They complete short questionnaires (on dizziness, anxiety, depression, cognitive symptoms, and daily functioning), and their ENT specialist encodes the results of the vestibular tests already performed as part of their usual care. No additional medical tests are required for the study.

By comparing data from several centers in Belgium, France, and the United States, this project seeks to provide a more complete picture of vestibular disorders worldwide and to support the development of better diagnostic tools and more personalized rehabilitation strategies.

Conditions

Vestibular Disease; Vestibular Dysfunction

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Vestibular

Patients with vestibular loss diagnosed by senior ENT doctors with the gold standard ENT measures (caloric testing, head impulse test and/or vestibular evoked myogenic potential, ocular and cervical)

No interventions assigned to this group

Healthy controls

People with no vestibular loss

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Age between 18 and 90 years old.
• Vestibular loss diagnosed by senior ENT doctors

• Age between 18 and 90 years old.

Exclusion Criteria

• Previous neurological disorders (stroke, dementia, …)
• Current medication interfering with the testing (reducing reaction time).
• Visual difficulties interfering with the testing (Visual field reduction,…)
• Age below 18 years old.

For healthy controls :

• Previous neurological disorders (stroke, dementia, …)
• Current medication interfering with the testing (reducing reaction time)
• Visual difficulties interfering with the testing (Visual field reduction,…)
• Vertigo or balance complains or an history of previous vestibular disorder.
• Age below 18 years old.
• Not being able to understand the consigns of the task.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Université Catholique de Louvain

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Medical University of South Carolina

Charleston, South Carolina, United States

Cliniques universitaires Saint-Luc

Brussels, , Belgium

Hopital européen Marseille

Marseille, , France

Countries

United States; Belgium; France

Other Identifiers

ABMA-3

Identifier Type: -

Identifier Source: org_study_id