Source Monitoring Déficit in Neuropsychiatric Population

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-08

Study Completion Date

2026-07-31

Brief Summary

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the investigators will measure source-monitoring ability in patients with several neuropsychiatric condition and in healthy controls appaired in age, sex and educational level. Source-monitoring will be measured thanks to internal- and reality-monitoring informatic tasks.The investigators hypothesized patients with fronto-temporal abnormalities would show more marked deficits than patients with only frontal abnormalities.

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Detailed Description

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Source-monitoring abilities will be measured thanks to reality-monitoring testing (i.e. the ability to distinguish internal-generated events from external ones) and internal-monitoring testing (i.e. the ability to distinguish an imagined source from a performed one). A source-monitoring deficit have been demonstrated in patients with psychiatric conditions such as schizophrenia and seems linked to frontotemporal abnormalities (frontotemporal dysconnectivity and temporal hypoactivity). With a total of 150 patients, the investigators will include 30 patients per group: patients with pre-dementia stage Alzheimer, Alzheimer, Fronto-Temporal dementia, Lewy Body dementia or Parkinson and Bipolar Disorder, with the hypothesis that Bipolar Disorder patients will present less marked deficit. The investigators will recruit 150 healthy controls.

Conditions

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Psychiatric Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

2 arms

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Patients with with neuropsychiatric conditions

In this arm, five groups :

* Patients with DFT, diagnosed according Racovsky criteria
* Patients with Lewi Body dementia, diagnosed according McKeith criteria
* Patients with pre-demential Alzheimer, diagnosed according Dubois criteria
* Patients with Alzheimer, diagnosed according MMSE
* Patients with bipolar disorder, diagnosed according DSM 5

Group Type EXPERIMENTAL

Monitoring source test

Intervention Type OTHER

Internal- and external-monitoring correct responses and inversions

Healthy subjects

Healthy controls appaired in age, sex and educational level

Group Type ACTIVE_COMPARATOR

Monitoring source test

Intervention Type OTHER

Internal- and external-monitoring correct responses and inversions

Interventions

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Monitoring source test

Internal- and external-monitoring correct responses and inversions

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subjects who gave their free and informed consent;
* Men and women;
* Aged 18 to 80;
* Having normal or corrected vision;
* Mastering the French language (read and spoken);
* All subjects will not have a working memory deficit preventing the test from being passed (MMSE short version):AM patients should have a score of \<MMSE \<26; Patients with pre-dementia AD will be diagnosed according to Dubois criteria (Dubois et al., 2016); patients with early FTD will be diagnosed according to Rascovsky's criteria (Rascovsky et al., 2011); Patients with DCL will be diagnosed according to McKeith's criteria (McKeith et al., 2005), TBP patients will be diagnosed using DSM 5 criteria (Arlington VA, 2013).