Sensorimotor Integration in Patients With Tourette Syndrome

NCT ID: NCT07290920

Last Updated: 2025-12-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-03-20
• Study Completion Date: 2025-12-03

Brief Summary

The present study investigates the mechanisms underlying the sense of agency in patients with Tourette Syndrome (TS). Previous research has shown that individuals with TS display impairments in both explicit and implicit aspects of agency, possibly due to altered integration between sensory feedback and motor predictions. To explore this hypothesis, the study will examine the phenomenon of sensory attenuation, a marker of sensorimotor integration that has not yet been investigated in this population. Furthermore, the study will assess how alterations in sensorimotor integration are related to the severity of TS symptoms.

Detailed Description

The present study aims to investigate the mechanisms underlying the sense of agency in patients with Tourette Syndrome (TS). Previous evidence indicates that individuals with TS exhibit abnormalities in both explicit and implicit (absent intentional binding) experiences of agency. According to a recent theoretical framework, such alterations may stem from impaired sensorimotor integration - specifically, a dysfunction in the ability to combine sensory feedback with motor predictions about the consequences of one's own actions. This deficit may not only affect motor control but also the awareness of self-generated movements, thereby compromising the distinction between self-produced and externally produced actions.

To test this hypothesis, the study will employ the Force Matching Task (FMT), a well-established paradigm used to assess sensory attenuation - the reduced perception of intensity for self-generated sensations compared to externally generated ones. In this task, participants are asked to reproduce a force applied to their finger either by pressing directly with their own finger (self-generated condition) or by controlling a mechanical device (externally generated condition). In healthy individuals, self-generated forces are typically perceived as weaker due to predictive motor mechanisms. A reduced or absent sensory attenuation effect would indicate altered sensorimotor integration.

The primary aim of the study is therefore to evaluate whether patients with Tourette Syndrome show atypical sensory attenuation compared to healthy controls, as an index of altered sensorimotor integration underlying the sense of agency. The secondary aim is to examine the relationship between the degree of sensory attenuation and clinical symptom severity, to determine whether deficits in sensorimotor integration are associated with the intensity of tic expression or other clinical features of the disorder.

Conditions

Tourette Disorder; Sensory Gating

Keywords

Tourette Syndrome; Sense of agency; Sensorimotor integration; Sensory attenuation; Motor control; Predictive processing

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Tourette Syndrome Patients

Patients affected by Tourette Syndrome

No interventions assigned to this group

Healthy controls

Individuals without neurological or psychiatric disorders

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

For Tourette Syndrome group:

• Clinical diagnosis of Tourette Syndrome (TS) according to DSM-5 criteria
• Age between 18 and 65 years
• Ability to understand and comply with study procedures
• Written informed consent provided

For Healthy Control group:

• No current or past history of neurological or psychiatric disorders
• Age between 18 and 65 years
• Matched to the TS group for age, sex, and education level
• Ability to understand and comply with study procedures
• Written informed consent provided

Exclusion Criteria

• History of significant neurological disorders (e.g., brain injury or dementia) or major psychiatric disorders (with the exception of conditions commonly associated with Tourette Syndrome, such as Obsessive-Compulsive Disorder, ADHD, depression, and anxiety);
• Failure or refusal to provide written informed consent;
• Confirmed pregnancy (self-reported) and/or breastfeeding.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

IRCCS Ospedale Galeazzi-Sant'Ambrogio

Milan, Italy, Italy

Countries

Italy

References

Delorme C, Salvador A, Voon V, Roze E, Vidailhet M, Hartmann A, Worbe Y. Illusion of agency in patients with Gilles de la Tourette Syndrome. Cortex. 2016 Apr;77:132-140. doi: 10.1016/j.cortex.2016.02.003. Epub 2016 Feb 17.

Reference Type: BACKGROUND

PMID: 26963083 (View on PubMed)

Zapparoli L, Seghezzi S, Zirone E, Guidali G, Tettamanti M, Banfi G, Bolognini N, Paulesu E. How the effects of actions become our own. Sci Adv. 2020 Jul 1;6(27):eaay8301. doi: 10.1126/sciadv.aay8301. Print 2020 Jul.

Reference Type: BACKGROUND

PMID: 32937445 (View on PubMed)

Brown H, Adams RA, Parees I, Edwards M, Friston K. Active inference, sensory attenuation and illusions. Cogn Process. 2013 Nov;14(4):411-27. doi: 10.1007/s10339-013-0571-3. Epub 2013 Jun 7.

Reference Type: BACKGROUND

PMID: 23744445 (View on PubMed)

Other Identifiers

ISM_L3053

Identifier Type: -

Identifier Source: org_study_id